宫颈注射利多卡因结合局部黏膜表面麻醉在妊娠终止术中的应用

Cervical Injection of Lidocaine Combining With Local Mucosal Surface Anesthesia in the Application of Pregnancy Termination

目的探讨利多卡因在妊娠终止术中的临床价值。方法选择2009年1月至12月,妊娠时间<10孕周,在湖北省孝感市中心医院行妊娠终止术患者328例为研究对象。将其随机分为观察组(使用宫颈注射利多卡因+宫颈口黏膜表面麻醉,n=164)和对照组(常规手术,n=164)。两组患者年龄、孕龄、孕次、产次及体重等比较,差异无显著意义(P>0.05)。观察两组患者宫颈松弛程度、术中疼痛、出血量等(本研究遵循的程序符合湖北孝感市中心医院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书)。结果观察组和对照组患者宫颈松弛程度总有效率分别为87.20%和18.90%,两组比较,差异有显著意义(P<0.01)。观察组和对照组术中镇痛总有效率分别为80.49%和16.46%,两组比较,差异有显著意义(P<0.01)。结论宫颈注射利多卡因+宫颈口黏膜表面麻醉用于妊娠终止术,可减轻患者痛苦,预防妊娠终止术综合征,效果满意且价格低廉,操作简便,易于推广。

Objective To study clinical effects of lidocaine in pregnancy termination.Methods From January to December 2009,328 women of pregnancy week within 10 weeks who had pregnancy termination were randomly divided into observation group（cervical injection of lidocaine ＋ cervix mucosal surface anesthesia,n=164）and control group（routine surgery,n=164）.There had no statistically significant difference of age,gestational age,gravidity,parity,and weight between two groups（P0.05）.Degrees of cervical relaxation,pain,bleeding amount were observed.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Xiaogan Center Hospital.Informed consent was obtained from all participants.Results Total effective rate of cervical relaxation in observation group and control group were 87.20% and 18.90%,respectively（P0.01）.Total effective rate of analgesic effects in observation group and control group were 80.49% and 16.46%,respectively（P0.01）.Conclusion Cervical injection of lidocaine plus cervix mucosal surface anesthesia which used in pregnancy termination could relieve pain,prevent patients from postoperative syndrome.