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自然杀伤T细胞与支气管哮喘的研究进展 被引量：3

Research Progress of Natural Killer T Cells and Bronchial Asthma
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摘要 自然杀伤(natural killer,NK)T细胞是一种同时具有自然杀伤细胞和T细胞部分表型及功能的细胞亚群,能将先天性免疫应答和获得性免疫应答连接起来,限制性识别CD1d-糖脂抗原,并通过调节细胞因子的分泌,影响辅助性T细胞1型(T help cell type1,Th1)/Th2平衡,广泛参与免疫调节。近年研究发现,自然杀伤T细胞对哮喘Th1/Th2失衡及气管高反应(airway hyper responsiveness,AHR)产生起重要作用。本研究就自然杀伤T细胞的特征及其与支气管哮喘关系的最新研究进展,综述如下。 Natural killer I（NIX 1 ）cells are a umque subset oI tympnocytes,wmcn express botn T and natural killer （NK） cell surface markers as well as functional characteristics. They connect innate and acquired immunity,restrictedly recognize glycolipid antigens presented by CD1d molecule and influence the balance between T helper cell type 1 （Thl）and Th2 by regulating the secretion of cytokines. Natural killer T cells participate in the immune regulation generally. Focus on recent years found that natural killer T cells played important roles in Thl/Th2 imbalance and airway hyper responsiveness （AHR） of asthma. This paper reviewed the progress of the characteristics of natural killer T ceils and the association with bronchial asthma.
作者 卢燕鸣 曹兰芳
机构地区 上海交通大学医学院附属仁济医院儿科
出处 《中华妇幼临床医学杂志（电子版）》 CAS 2011年第4期305-308,共4页 Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金 上海交通大学医学院横向课题(2010HX003)~~
关键词 自然杀伤T细胞 支气管哮喘 免疫平衡 natural killer T （NKT）cell bronchial asthma immune balance
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献22

  • 1Halder RC,Aguilera C, Maricic I,et al. TypeⅡ NKT cell-media- ted anergy induction in type Ⅰ NKT cells prevents inflammatory liver disease [J]. J ClinInvest, 2007, 117(8): 2302-2312.
  • 2Bendelac A, Savage P B, Teyton L. The biology of NKT cells[J]. Annu Rev Immunol, 2007,25: 297-336.
  • 3Godfrey D1, Stankovic S, Baxter AG. Raising the NKT cell family[J].Nat Immunol, 2010, 11(3):197-206.
  • 4Kronenberg M, Engel I. On the road:Progress in finding the u- nique pathway of invariant NKT cell differentiation [J]. Curr Opin Immunol, 2007, 19(2): 186- 193.
  • 5Godfrey DI, Berzins SP. Control points in NKT2 cell development [J]. Nat Revlmmunol, 2007, 7(7): 505-518.
  • 6Yu KO, Im JS, Molano A, et al. Modulation of CDla-restricted NKT cell responses by using N-acyl variants of (alphal)-galacm- sylceramides [J]. Proc NatlAead Sci USA, 2005, 102(9): 3383- 3338.
  • 7Ono 6K, Yanagawa Y, Minami K, etal. Thl or Th2 balance regu- lated by interaction between dendritic cells and NKT cells [J].Im- munol Res, 2007, 38 (1-3): 319 332.
  • 8Akbari O, Stock P, Meyer E, et al. Essential role of NKT cells producing 1L-4 and IL-13 in the development of allergn-induced air- way hyperreactivity[J]. Nat Med, 2003, 9(5): 582-588.
  • 9Meyer EH, Goya S, Akbari O, et al. Glycolipid activation of in- variant T cell receptor + NKT ceils is su{ficient to induce airway hyperreactivity independent of conventional CD4 + T cells [J]. Proc Natl Acad Sci USA, 2006, 103(8): 2782-2787.
  • 10Pichavant M, Goya S, Meyer EH, et al. Ozone exposure in a mouse model induces airway hyperreactivity that requires the pres- ence of natural killer T cells and IL-17 [J]. J Exp Med, 2008, 205(2): 385-393.

同被引文献26

  • 1黄建军.小儿支气管哮喘45例临床分析.中外健康文摘,2009,6(2):101-102.
  • 2Anderson GP. Endotyping asthma: New insights into key pathogenic mechanisms in a complex, heterogeneous disease[J]. Lancet, 2008,372(9643):1107-1119.
  • 3Ahn JH, Kim CH, Kim YH, et al. Inflammatory and remodeling events in asthma with ehronie exposure to house dust mites: A murine model[J]. J Korean Med Sci, 2007,22(6):1026-1033.
  • 4Li J, Sun B, Huang Y, et al. A multicentre study assessing the prevalence of sensitizations in patients with asthma and/or rhinitis in China[J]. Allergy, 2009,64(7) :1083-1092.
  • 5Bendelac A, Savage PB, Teyton L. The biology of NKT cells[J]. Annu Rev Immunol, 2007,25: 297-336.
  • 6Gadue P, Stein PL. NK T cell precursors exhibit differential cytokine regulation and require hk for efficient maturation[J]. J Immunol, 2002,169(5) :2397-2406.
  • 7Townsend MJ, Weinmann AS, Matsuda JL, et al. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells[J]. Immunity, 2004,20(4) :477-494.
  • 8Matsuda JL, Zhang Q, Ndonye R, et al. T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells[J]. Blood, 2006, 107 (7) : 2797-2805.
  • 9Topilski I, Flaishon L, Naveh Y, et al. The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing[J]. Eur J Immunol, 2004,34 ( 4 ) : 1068-1076.
  • 10Devereux G, Litonj ua AA, Turner SW, et al. Maternal vitamin D intake during pregnancy and early childhood wheezing[J]. Am J Clin Nutr,2007,85(3) :853-859.

引证文献3

二级引证文献17

中华妇幼临床医学杂志（电子版）
2011年 第4期

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