金钮扣中三萜类化学成分研究

Study on triterpenes from Solanum torvum

目的:对金钮扣中的三萜类化学成分进行研究。方法:以95%乙醇提取,应用硅胶、Sephadex LH-20等柱色谱法进行分离,用NMR和MS分析确定化合物结构。结果:从金钮扣95%乙醇提取物的石油醚萃取部位中分离得到6个三萜化合物,分别为3β-乙酰基齐墩果酸(1)、3β-乙酰氧基-11α,12α-环氧-齐墩果烷-28,13β-内酯(2)、齐墩果酸(3)、熊果酸(4)、2α-羟基齐墩果酸(5)、2α,3β-二羟基乌苏酸(6)。结论:化合物1～6均为首次从该植物中得到。

Objective： To study on the chemical constituents of Solanum torvum. Method： The aerial parts of S. torvum swar- tz were extracted with 95% alcohol and the constituents were isolated and purified by chromatographic silica gel and Sephadex LH-20. Their structures were determined by NMR and MS spectral analysis. Result： Six triterpenes were isolated and identified as 3β- acetyloleanolic acid（ 1 ）, 3-O-acetyl-11α, 12α-epoxy-oleanan-28, 13β-olide （ 2）, oleanolic acid （ 3 ）, ursolic acid （ 4 ）, 2α-hydroxy- oleanolic acid （5）, 2ct, 3β-dihydroxyursolic acid （6）. Conclusion： All compounds were obtained from this plant for the first time.