17β雌二醇对去势后雌性大鼠颅内动脉血管内皮细胞NF-κB和ICAM-1表达的作用被引量：1

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摘要目的探讨雌激素对颅内动脉血管壁炎症反应的可能作用。方法自发性高血压SHR雌性大鼠20只,随机分为两组:卵巢切除去势对照组(对照组)和去势后雌激素替代组(观察组),每组10只。放射免疫法检测各组静脉血的雌激素水平,获取标本后分别运用免疫组化和Western blot检测颅内动脉Willis环血管壁组织的核因子-κB(NF-κB)和细胞间黏附因子-1(ICAM-1)的表达和蛋白含量。结果观察组的雌激素水平较对照组明显增高(P<0.01)。免疫组化显示,在对照组血管壁NF-κB和ICAM-1的表达明显高于观察组;West-ern blot蛋白分析发现,观察组颅内动脉血管壁的NF-κB和ICAM-1表达明显低于对照组(P<0.01)。结论雌激素能降低卵巢切除去势大鼠血管壁NF-κB和ICAM-1的表达,抑制血管壁的炎症反应。

作者刘安民黄鸣蔡望青

机构地区中山大学孙逸仙纪念医院神经外科广东省佛山市南海区官窑医院

出处《广东医学》 CAS CSCD 北大核心 2011年第14期1817-1819,共3页 Guangdong Medical Journal

基金广东省医学科研基金资助项目(编号:A2008185)

关键词颅内动脉雌激素炎症反应

分类号 R644 [医药卫生—外科学]

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