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氯胺酮对糖尿病痛性周围神经病变大鼠机械痛阈的影响

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摘要 目的评价氯胺酮对糖尿病痛性周围神经病变大鼠机械痛阈的影响。方法腹腔注射1%链脲佐菌素(STZ)60 mg/kg诱导大鼠糖尿病痛性周围神经病变模型,在造模成功的痛过敏糖尿病大鼠中取20只随机分为糖尿病组(DM组,n=10)和氯胺酮治疗组(KM组,n=10)。KM组、DM组在第28天后分别每天腹腔注射10mg/kg的氯胺酮和等体积的生理盐水1周。于注射STZ前(T1)、注射STZ后2(T2)、7(T3)、14(T4)、21(T5)、28(T6)、35(T7)d取尾静脉血0.1 mL测定血糖水平;于T1、T3~7时测定大鼠右后爪缩足机械反应阈值(PWT)。结果与DM组比较,KM组T1~7时血糖水平无显著变化(P>0.05),T1~6时PWT无显著变化(P>0.05),T7时PWT升高(P<0.05);与T1比较,T2~7时DM、KM组血糖升高(P<0.01);与T6时比较,T7时KM组PWT升高(P<0.05)。结论氯胺酮减轻了糖尿病痛性周围神经病变大鼠疼痛。
出处 《广东医学》 CAS CSCD 北大核心 2011年第14期1826-1827,共2页 Guangdong Medical Journal
基金 广东省医学科研基金资助项目(编号:B2009235)
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