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正常血清PSA前列腺癌7例临床分析 被引量:1

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摘要 目的总结和探讨正常血清PSA前列腺癌患者临床表现及预后。方法回顾性分析7例就诊时正常血清PSA前列腺癌患者的临床表现、血清PSA水平、Gleason评分与分级、免疫组化的结果及临床预后。结果正常血清PSA前列腺癌患者的病理可分为高分化、中分化、未分化及特殊类型如黏液腺癌。其中3例病情凶险,短期内死亡。结论正常血清PSA前列腺癌患者的临床表现变化多端。当高分化时属于潜伏型,免疫组化PSA常多为阳性,预后良好;当中分化时,一种类似于高分化潜伏型,另一种为进展型,病情凶险,抗雄疗效差;而未分化型,是因为血清PSA正常是因为前列腺上皮细胞已失去分泌PSA的功能,病程短,预后凶险。
出处 《广东医学》 CAS CSCD 北大核心 2011年第14期1864-1865,共2页 Guangdong Medical Journal
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参考文献10

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二级参考文献9

  • 1吴阶平.吴阶平泌尿外科学[M].济南:山东科学技术出版社,2004.589-591.
  • 2Stein BS,Vangone S,Petersen RO,et al.Immunoperoxidase localization of prostate-specific antigen[J].Am J Surg Pathol,1982,6(6):553-557.
  • 3Ford TF,Butcher DN,Masters JR,et al.Immunocytochemical localizalion of prostate-specific antigen:specificity and application to clinical practice[J].Br J Urol,1985,57(1):50-55.
  • 4Stege RH,Tribukait B,Carlstrom KA,et al.Tissue PSA from fine-needle briopsies of prostatic carcinoma as related to serumPSA clinical stage,cytolopgical grade,and DNA ploidy[J].Prostate,1999,38(3):183-188.
  • 5Babaian RJ,Camps JL,Frangos DN,et al.Monoclonal prostate-specific antigen in untreated prostate cancer Relationship to clinical stage and grade[J].Cancer,1991,67(8):2200-2206.
  • 6Lerner SE,Jacobsen SJ,Lilja H,et al.Free,complexed,and total serum prostate-specific antigen concentration and their proportions in predicting stage,grade,and deoxyribo,nucleic acid ploidy in patients with adenocarcinoma of the prostate[J].Urology,1996,48(2):240-248.
  • 7Cohen RJ,Haffejee Z,Steele GS,et al.Advanced prostate cancer with normal serum prostate-specific antigen values[J].Arch Pathol Lab Med,1994,118(11):1123-1126.
  • 8Sella A,Konichezky M,Flex D,et al.Low PSA metaslatic androgen-independent prostate cancer[J].Eur Urol,2000,38(3):250-254.
  • 9Nishio R,Furaya Y,Nagakawa O,et al.Metastatic prostate cancer with normal level of serum prostatic-specific antigen[J].Inter Urol Nephrol,2003,35(2):189-192.

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