甲泼尼龙治疗毛细支气管炎的疗效分析

Efficacy of Methylprednisolone in Treating Bronchiolitis in Infants

目的:分析甲泼尼龙治疗毛细支气管炎(简称毛支炎)的疗效。方法:将64例我科确诊为毛支炎的患儿按就诊先后随机抽签分为治疗组34例和对照组30例,在综合治疗的基础上,对照组给予地塞米松0.25～0.5 mg/(kg.d),分2次静脉滴注;治疗组给予甲泼尼龙2 mg/(kg.次),2次/d静脉滴注,疗程5 d左右。结果:治疗组总有效率91.2%,对照组总有效率60.0%,治疗组总有效率显著高于对照组,差异有统计学意义(χ2=8.6,P<0.01)。治疗组患儿在喘憋、肺部哮鸣音、湿性啰音消失时间及住院天数方面与对照组比较明显缩短,差异有统计学意义(P<0.01)。结论:甲泼尼龙治疗毛支炎疗效明显优于地塞米松。

Objective：To analyze the effect of methylprednisolone on bronchiolitis.Method：Sixty-four cases with bronchiolitis were randomly divided into two groups： the treatment group with 34 cases and the control group with 30 cases.On the basis of the comprehensive treatment of the two groups,the control group was given intravenous dexamethasone 0.2~0.5 mg/kg,q12h,while treatment group was treated with methylprednisolone 2 mg/kg,q12h.The treatment was lasted for 5 days.Results：The total effective rate of treatment group（91.2%）was higher than the control group（60.0%）（χ2=8.6,P0.01）.The time need for the disappearance of gasp,pulmonary wheeze,moist rales of chest and the hospitalization days of treatment group were significantly shorter than those of the control group respectively.The difference was statistically significant（P0.01）.Conclusions：The effect of methylprednisolone is better than dexamethasone significantly in treatment of bronchiolitis.