2009～2010年开封市儿童医院临床常见病原菌分布及耐药性分析

Analysis of Clinical Common Pathogenic Bacteria Distribution and Drug Resistance in Kaifeng Children's Hospital from 2009 to 2010

目的:分析临床常见病原菌分布及其对抗菌药物的耐药情况,为临床合理使用抗菌药提供参考。方法:从送检的5 049份标本中检出致病菌1 096株,采用DL-96自动细菌测定系统进行药敏试验,SPSS13.0软件对致病菌及药敏试验进行分析。结果:检出的1 096株病原菌中,G-菌占64.23%,G+菌占27.92%,真菌占7.85%。最常见病原菌为大肠埃希菌、肺炎克雷伯菌、凝固酶阴性葡萄球菌、铜绿假单胞菌、金黄色葡萄球菌、阴沟肠杆菌。所分离的G+菌对万古霉素、替考拉宁高度敏感,G-菌对亚胺培南/西司他丁、美罗培南高度敏感。结论:分离株耐药现象普遍存在,临床应重视病原学检查,开展细菌耐药性监测,合理使用抗生素。

Objective：To provide a reasonable reference for the clinical usage of antibiotics by analyzing the distribution of common pathogens and their resistance to antimicrobial drugs.Methods： One thousand and ninety-six strains of pathogenic bacteria were examined from 5,049 samples.Drug sensitivity test were conducted and SPSS 13.0 was used to analyze the distribution of pathogenic bacteria.Results：Together 1,096 pathogens were detected with the detection ratio of 21.71%,in which Gram-negative bacteria were 64.23%,Gram-positive bacteria were 27.92% and fungi were 7.85%.The most common bacteria were Escherichia coli,Klebsiella pneumoniae,Coagulase negative staphylococcus,Pseudomonas aeruginosa,Staphylococcus aureus,Enterobacter cloacae.Statistics of drug sensibility test suggested,Gram-positive bacteria were highly sensitive to vancomycin and teicoplanin.Gram-negatives were highly sensitive to imipenem/cilastatin and meropenem.Conclusions：The drug resistance seriously exists in clinics,therefore,there is an urgent need for the surveillance of bacterial resistance and rational usage of antibiotics.