表皮生长因子(EGF)与肿瘤的放射性核素显像诊断和治疗

EPIDERMAL GROWTH FACTOR AND IMAGINE DIAGNOSIS AND THERAPY OF TUMOUR WITH RADIONUCLIDES

肿瘤的分化程度、大小、阶段、有丝分裂指数或复发等特征与肿瘤的表皮生长因子受体密度有显著的正比关系,且90%的肿瘤表面有高密度的表皮生长因子受体表达,其中54%的恶性肿瘤的表皮生长因子受体能与外源性配体结合,因此,放射性核素标记表皮生长因子可实现恶性肿瘤的显像诊断和治疗。本文着重介绍放射性核素标记表皮生长因子的肿瘤受体显像诊断和治疗的研究现状和临床意义。

It has a direct proportin correlation between the epidermal growth factor receptor levels of tumour and tumour differentiation degree, tumour sizes, stage, mototic index or cancer recurrence. Epidermal growth factor receptor is detected in 90% of the tumours, in which, 54% of epidermal growth factor receptor of malignant tumours can link with external genous ligand. Therefore, radionuclinde labelled epidermal growth factor will bring about the imaging diagnosis and therapy of malignant tumours. The research present situation and clinical significance of radionuclinde labelled epidermal growth factor for receptor imaging diagnosis and therapy of tumour are emphatically elaborated in the paper.