高压氧治疗对脑梗死患者血清MDA和SOD的影响

The Changes of Serum MDA and SOD in the Patients with Cerebral Infarction Treated by Hyperbaric Oxygenation

为探讨高压氧（HBO）对脑梗死患者血清脂质过氧化产物丙二醇（MDA）和超氧化物歧化酶-1（SOD－1）的浓度变化及意义．对50例患者随机分为HBO组32例行常规加高压氧治疗，常规组18例行单纯常规治疗，另30例健康志愿者作为正常组，采用硫代巴比妥酸比色法检测MDA、放射免疫法测定SOD-1。结果：治疗前MDA和SOD－1，HBO组与常规组差异无显著性（P＞0．05）．与正常组比较差异均有显著性（P＜0．01）．MDA和SOD－1呈负相关，MDA高伴随SOD－1低的患者病情较重。治疗后MDA仍较高和SOD－1低的患者其疗效与预后均差。HBO组MDA降低、SOD－1升高均较常规组显著（P＜0.01）；HBO组有效率也较常规组高（P＜0．05）。提示MDA和SOD-1与疾病的严重程度有关．高压氧治疗能观察其变化．有利于判断疗效与预后。

The changes of serum malonic dialdehyde (MDA) and superoxide dismutase (SOD-1 ) in the patients with cerebral infarction before and after the treatment of hyperbaric oxygenation (HB()) were investigated. Fifty patients were randomly divided into two groups: HBO group and control group and 30 health volunteers as health group. The activities of MDA were measured by using spectrometry and SOD-1 by redio-immunoassay. The results showed that be fore treatment there was no significant difference in the activities of MDA or SOD-1 between the HBO group and control group, but there was a significant difference between the HB() or controI groups and health group (P<0. 01 ). There was a negative correlation between MDA and SOD-1 in treatment groups. The outcome would be worse if the patients showed higher MDA with lower SOD-1. After treatment. the patients with higher MDA and lower SOD-1 had poor therapeutic effects and worse prognosis. The decrease of MDA and the lncrease of SOD-1 in HBO group was more significant than in the control group and the effective rate of Iinguistic functional restoration and limbs functional reccovery was higher (P<0. 05). It was concluded that the changes of activities of MDA and SOD-1 were related with the severity of brain injury, prognosis of patients and outcome of HBO treatment. The observation on them was beneficial to the evaluation of therapeutic effects and prognosis during the treatment of HBO.