对高危妊娠孕妇血清雌三醇和胎盘泌乳素检测的研究

The study of combined measurement of maternal serum unconjugated estriol and human placetal lactonen for high risk pregnancy

目的探讨血清游离雌三醇(uE3)和胎盘泌乳素(HPL)测定对监测高危妊娠胎儿-胎盘功能的应用价值。方法对192例孕37周以上高危妊娠孕妇及正常孕妇(50例)血清uE3和HPL水平进行化学发光免疫分析方法测定,血清中uE3与HPL水平低于正常值者为胎盘功能减退。结果高危妊娠组胎盘功能减退阳性率:uE3为31.8%、HPL为28.6%、uE3联合HPL为46.6%,正常对照组胎盘功能减退阳性率:uE3为4%、HPL为4%。高危妊娠组胎盘功能减退阳性率高于正常对照组;高危妊娠组uE3与HPL联合测定胎盘功能减退阳性率高于单项测定。结论 uE3与HPL联合测定能提高高危妊娠胎儿-胎盘功能低下的诊断率。

Objective To evaluate the value of combined measurement of matemel serum unconjugated estriol（uE3） and human placetal lactogen（HPL） for determination of fetus-placenta function for monitoring high risk pregnancy.Methods Serum uE3 and HPL levels were measured with chemiluminescence immunoassay（CLIA）in 50 pregnant women and 192 women with high risk pregnancy for more than 37 gestational age. The matemel serum uE3 and HPL levels which below normals was seemed as fetus-placenta function decline.Results The positive rate of fetus-placenta function decline in the group of high risk pregnancy was respectly uE3 for 31.8%,HPL for 28.6% and uE3 combined HPL for 46.6%,which in normal control group was uE3 for 4% and HPL for 4%。The positive rate of fetus-placenta function decline in the group of high risk pregnancy was higher than normal control group.Combined measurement of matemal sarum unconjugated estriol and human placetal lactogen sensitive than separable program for monitoring fetus-placenta function decline in the group of high risk pregnancy.Conclusion Combined measurement of matemal sarum unconjugated estriol and human placetal lactogen is useful determination of fetus-placenta function in high risk pregnancy.