恶性肿瘤、高血压病患者及健康人血液流变学观察

AN OBSERVATION ON HEMORRHEOLOGY IN PATIENTS WITH MALIGNANT TUMOR AND HYPERTENSION AND HEALTHY SUBJECTS

目的 探讨恶性肿瘤与血液流变学的关系。方法 对恶性肿瘤患者４４ 例与高血压病患者４２ 例及健康人４２例的血液流变学进行观察分析。结果 恶性肿瘤患者的红细胞沉降率、血浆粘度、血栓长度、血小板粘附率均高于高血压组及正常组（Ｐ＜ ０．０５ 和Ｐ＜ ０．０１）；红细胞压积低于高血压组及正常对照组（Ｐ＜ ０．０１）；血栓湿重明显高于正常组（Ｐ＜ ０．０１）；全血高切粘度平均值低于高血压组（Ｐ＜ ０．０５），有显著性差异，晚期转移组的红细胞沉降率，血浆粘度高于非转移组（Ｐ＜ ０．０５）；血球压积低于非转移组（Ｐ＜ ０．０１）。结论 恶性肿瘤患者存在着明显的血液流变学异常，晚期患者尤其明显，提示恶性肿瘤患者处于高粘高凝状态，检测血液流变学对判断病情预测预后有一定意义，改善血液粘滞状态可以延缓病情，防止转移，预防血栓并发症发生。

Objective To study the relation between malignant tumor and hemorrheology.Methods Measurement with instrument on indexes of hemorrheology in 44 cases of malignant tumor,42 cases of hypertension and 42 cases of healthy subjects,and then analysing the results.Results The results indicated that indexes of erythrosedimentation rate(ESR),plasma vascocity(PLV),thrombus length and platelet adhesion rate in malignant tumors were higher than in hypertension and healthy subjects(P<0.01).Hemotocrit in malignant tumor was lower than hypertension and healthy subjects(P<0.01),but thrombus weight was distinctly higher than in control group(P<0.01).High shear rate of whole blood viscosity was lower than hypertensive group(P<0.05),ESR and PLV in malignant tumor of metastasis was remarkly higher than non metastasis (P<0.05),but HCT was lower than the latter (P<0.01).Conclusion The abnormality of hemorrheology in cases of malignant tumor is common,especially in cases of metastatic malignant tumor is more prominent. It suggested that the cases of malignant tumor are offen in state of hyperviscosity and hypercoagulation,so the indexes of hemorrheology in judging clinic status and prognosis,or attempt to prevent metastasis and control advance may be of significance.