前列腺癌综合指数及临床意义初探

The comprehensive index of prostate cancer and it's clinical significance: a primitive clinical study

目的：寻求一种诊断前列腺癌（PCa）的更有效方法。方法：对PCa78例和前列腺增生症73例临床资料进行分析，并根据前列腺特异抗原（PSA）、直肠指检及年龄与PCa的相关性设计出一公式，将直肠指检所得的前列腺大小、给节、硬度进行量化，所得数值称为“前列腺癌综合指数（Ipca）”。结果：当Ipca以5．80为阈值时，其敏感性为0．83，特异性为0．93；当Ipca以4．23为阈值时，其敏感性为0．95，特异性为0．45，较PSA诊断PCa有显著提高。结论：Ipca可作为诊断PCa的参考指标，具有临床实用价值。

Purpose:To look for a more effective way to diagnose prostatic cancer(Pca). Methods: 78 cases of PCa, 73 cases of BPH were analyzed, according to the relationship between thefactors (PSA, DRE, Age) and PCa, a formula was designed, and size, nodule, consistency ofprostate palpated by DRE were quantified. The result is named n Comprehensive Index of ProstaticCancer (Irm)'. Results: When the threshold of Ipa is 5. 8, the sensitivity is 83% while the specificity is 93%. When the threshold of Ipca. is 4. 23, the sensitivity is 95% while the specificity is45%. Conclusions: Ipca is a valuable index in diagnosis of prostatic cancer.