摘要
目的探讨血清NT-proBNP和尿酸水平与NYHA(纽约心脏病学会)心功能分级之间的相关性。方法对153例老年慢性心衰(CHF)患者就诊后24小时内取静脉血,并随机选取老年健康体检者31例为对照组,采用电化学发光法测定血清NT-proBNP,同时采用尿酸酶-过氧化物酶法测定血清尿酸,分析血清NT-proBNP和尿酸浓度与NYHA心功能分级之间的关系。结果心功能I～IV级患者血清NT-proBNP逐步增加(P<0.05);心功能II～IV级患者尿酸逐步增加(P<0.05),NT-proBNP与尿酸的相关系数为0.310。结论老年慢性心衰患者的血清NT-proBNP与尿酸水平与心功能相关,心衰越重,血清NT-proBNP与尿酸水平越高,NT-proBNP与尿酸有一定的相关性,但NT-proBNP检测灵敏度更高。
Objective To investigate the correlation between serum NT-proBNP,uric acid and NYHA（New York Heart Association） heart functional classifications.Methods Serum NT-proBNP and uric acid of 153 aged patients with CHF and 31 normal persons were tested by ECLIA and uricase-POD quantitative method in the fist 24 hours.The relationship between them and NYHA heart levels was analyzed.Results The concentration of serum NT-proBNP and uric acid were increased with the degree of NYHA from I to IV（P 0.05）.The correlation coefficient between NT-proBNP and uric acid was 0.310.Conclusions There is positive correlation between serum NT-proBNP and uric acid and NYHA class in aged patients with CHF.The more serious the heart failure is,the higher concentration of NT-proBNP and uric acid it is.And serum NT-proBNP is a more sensitive index.
出处
《临床医学工程》
2011年第8期1184-1185,1189,共3页
Clinical Medicine & Engineering
