慢性乙型重型肝炎近期预后的指标探讨

Factors influencing the short-term prognosis of patients with chronic severe hepatitis B

目的回顾性分析影响慢性乙型重型肝炎(CHS)近期生存的相关因素。方法对155例CSH患者的临床资料进行回顾性多因素回归分析。结果本组患者3个月内生存60例(38.7%),死亡95例(61.3%);生存患者PTA(31.26±6.08%)、球蛋白(32.28±9.13g/l)明显高于死亡患者(26.11±9.76%和29.32±7.14g/l,P<0.01和P<0.05);生存患者TBIL(335.74±123.27μmol/L)、WBC(6.5±3.0×109/L)和中性粒细胞比值(64.42±14.59%)明显低于死亡患者(382.78±141.15μmol/L、8.8±5.4×109/L、71.63±11.37%,P<0.05、P<0.05、P<0.01);中性粒细胞比值、球蛋白和PTA与生存密切相关。结论研究影响慢性乙型重型肝炎病情近期预后的因素有重要的意义。

Objective To retrospectively analyze the factors influencing the short-term prognosis of patients with chronic severe hepatitis B（CSH）.Methods Clinical data of 155 patients with CSH were retrospectively analyzed.Results 60（38.7%）survived and 95（61.3%）died in this series;PTA（31.26±6.8%）and globulin（32.28± 9.13g/l）in survivals were obviously higher than those in dead（26.11±9.76% and 29.32±7.14g/l,P0.01,P0.05）;the TBIL（335.74±123.27μmol/L）,WBC（6.5±3.0×109/L）and neutrophil ratio（64.42±14.59%）in survivals were obviously lower than in dead（382.78±141.15μmol/L,8.8±5.4×109/L and 71.63±11.37%,P0.05,P0.05,P0.01）;neutrophil ratio,globulin and PTA were strongly related to patients＇prognosis.Conclusion It is important to predict the short-term prognosis of patients with CSH.