武汉某单位TTV流行期间患者肝组织学特征

Liver histologic characteristics of patients with TTV infection during an epidemic of TTV infection in Wuhan

目的 观察单一ＴＴＶ 感染患者肝组织学特征．方法 对某职业学校ＴＴＶ 感染流行期间１８ 例住院患者行肝活检组织检查，其中９ 例行电镜观察．结果 在肝穿刺标本１８ 例中，出现汇管区炎１４ 例（７７－８ ％ ） ，胆小管损害６ 例（３３－４ ％ ） ，肝小叶内灶状坏死７ 例（３８－９ ％ ） ，小泡性脂肪变（ 微脂滴）３ 例（１６－７ ％ ） ，汇管区纤维化２ 例（１１－１ ％ ） ． 电镜提示线粒体肿胀和溶酶体增加，未见病毒颗粒．结论 单一ＴＴＶ 感染可致患者肝组织轻度炎性病变，其特征是汇管区炎为主，部分伴胆小管损害．

AIM To observe the liver histologic characteristics of patients with isolated TTV infection in Wuhan. METHODS Eighteen hospitalized patients with TTV infection contracted during an epidemic in a professional school in Wuhan were liver biopsied, of them 9 samples were observed by electron microscopy. RESULTS The histologic characteristics were as follows: portal inflammation 77 8% (14/*!18), interlobular bile duct damage 33 4% (6/*!18), focus necrosis 38 9% (7/*!18), microvesicular fatty infiltration 16 7% (3/*!18), and portal tract fibrosis 11 1% (2/*!18). Under electron microscopy, it is shown that the mitochondria were swollen, the lysosome increased, no virus particle was found. CONCLUSION TTV infection may be solely responsible for the mild inflammation of liver in these patients, the characteristics of liver histology are portal inflammation and interlobular bile duct damage.