急性颅脑损伤患者血清白细胞介素-8和可溶性P-选择素的变化及临床意义

Changes and clinical significance of IL - 8, sP - selectin in the patients with acute traumatic brain injury

目的探讨急性颅脑损伤（TBI）后血清中白细胞介素-8（IL-8）和可溶性P-选择素（sP—selectin）的水平变化及其临床意义。方法采用ELISA法检测60例急性颅脑损伤患者不同时间血清IL-8、sP—selectin含量，按GCS评分分组并与对照组比较，进行统计学分析。结果急性颅脑损伤患者组IL-8、sP—selectin在发病后24h、3d和5d的血清水平显著高于对照组（P〈0．05），IL-8在发病后第7天仍显著高于对照组（P〈0．05）。发病后血清IL-8、sP—selectin水平与入院时GCS评分呈负相关（P〈0．01）。IL-8和sP—selectin两者在疾病的过程中呈正相关（P〈0．05）。结论IL-8、sP—selectin共同参与了急性颅脑损伤的病理生理过程，其测定对评估脑损伤的严重程度和预后有重要的临床意义。

Objective To study the changes of serum IL - 8, sP - selectin and their clinical significance in the patients with acute traumatic brain injury （TBI）. Methods The serum levels of IL- 8 and sP - selectin from 60 patients with TBI were measured at different times after injury by ELISA, then the correlation analysis among the serum levels of IL - 8, sP - selectin and GCS scores after injury was conducted and were compared with the control group. Results The serum levels of IL - 8, sP - selectin in the patients with acute TBI were significantly higher than those in the control group on the 24 h, 3rd, 5th day after acute TBI （ P 〈 0.05 ）. The serum levels of IL - 8 was still significantly higher than those in the control group on the 7th days after TBI （P 〈 0.05 ）. The serum levels of sP - selectin and IL -8 after injury were negatively correlated with GCS scores in TBI group （P 〈 0.01 ）. The serum levels of sP - selectin were positively correlated with IL - 8 after injury （ P 〈 0.05 ）. Conclusion IL - 8 and sP - selectin were involved in the pathological process of acute TBI. Determination of their serum levels was of clinical importance in the evaluation of injury severity and prognosis.