摘要
目的通过检测急性重症胰腺炎(SAP)患者血清IL-18、TNF-α及IL-10的变化,探讨早期血液灌流(hemoperfusion)的治疗效果。方法 20例患者采取血液灌流治疗(血液灌流组),同期22例患者未行血液灌流治疗(常规治疗组)。测定和比较治疗后第1、3、7天血清白介素18(IL-18)、肿瘤坏死因子(TNF-α)和白介素10(IL-10)的水平。结果两组IL-18、TNF-α、IL-10比较有统计学差异(P<0.05);血液灌流组住院天数比常规治疗组明显缩短(P<0.05)。血液灌流组死亡2例,常规治疗组死亡5例。结论血液灌流能有效清除SAP患者的血清IL-18和TNF-α,促进IL-10生成,提高早期抢救成功率,缩短住院天数。
【Objective】 To explore the effect of early hemoperfusion on patients with severe acute pancreatitis through the variation of serum cytokines.【Methods】 Serum IL-18,IL-10 and TNF-α levels were determined on day 1,3,and 7 after-therapy in the hemoperfusion group(20 cases) and the non-hemoperfusion group(22 cases).【Results】 In the hemoperfusion group,serum IL-18 and TNF-α were significantly lower than those in the non-hemoperfusion group on day 1,3,and 7 after-therapy(P〈0.05),while IL-10 was significantly higher than that in the non-hemoperfusion group on day 3 and 7 after-therapy(P〈0.05).Compared to the non-hemoperfusion group,the in-hospital duration was shorter(P〈0.05),and the death rate was lower in the hemoperfusion group.【Conclusions】 Hemoperfusion can eliminate serum IL-18 and TNF-α,promote the formation of IL-10,thus block inflammation reaction.It may become an important therapeutic method for severe acute pancreatitis.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2011年第12期1476-1478,共3页
China Journal of Modern Medicine