HPV分型检测对宫颈高度病变的筛查作用

Role of human papillomavirus type testing in screening of high grade cervical injury

目的观察HPV分型检测在宫颈高度病变筛查中的作用。方法对460例行液基细胞学及HPV分型检测患者资料进行回顾性分析,其中细胞学结果≥ASCUS的患者行宫颈病理学活检。结果 257例HPV检测阳性(阳性率为55.87%),其中分型检测感染频度前6位分别为16、58、52、18、68、53型。208例宫颈细胞学异常,确诊宫颈高度病变62例,其中高危型HPV+与HPV-者分别为58例和4例(P<0.01);145例ASCUS,活检确诊宫颈高度病变39例,其中高危型HPV+与HPV-者分别为37例和2例(P<0.01);45例LSIL,确诊宫颈高度病变12例,其中高危型HPV+与HPV-者分别为11例和1例(P<0.05);18例HSIL,确诊宫颈高度病变11例,其中高危型HPV+与HPV-者分别为10例和1例(P<0.01)。结论随着宫颈细胞学和组织病理学病变级别的升高,高危型HPV感染的阳性率呈上升趋势(P<0.05)。HPV分型检测对细胞学异常者宫颈高度病变筛查有重要意义。

【Objective】 To observe the role of human papilloma virus（HPV） type testing in screening of high grade cervical injury.【Methods】 The data from 460 women undergone both TCT and HPV testing were analyzed retrospectively,and the positive cases in cytology equal or over ASCUS were referred for biopsy.【Results】 A total of 257 women were detected positive in HPV（positive rate 55.87%）.The six leading types of HPV infection were as follows： 16,58,52,18,68 and 53.Among 208 cases with positive cytological detection,62 cases were diagnosed as high grade cervical injury,in which 58 were high-risk HPV positive and 4 were negative（P〈0.01）.Among 145 cases of ASCUS,39 cases were diagnosed as high grade cervical injury,in which 37 were high-risk HPV positive and 2 were negative（P〈0.01）.Among 45 cases of LSIL,12 cases were diagnosed as high grade cervical injury,in which 11 were high-risk HPV positive and 1 was negative（P〈0.05）.Among 18 cases of HSIL,11 cases were diagnosed as high grade cervical injury,in which 10 were high-risk HPV positive and 1 was negative（P〈0.01）.【Conclusions】 The positive rate of high-risk HPV increases with the increased grade of cervical lesions.HPV type detection is a useful tool for screening of high grade cervical injury.