含糖输液中热原加热灭活方法

METHOD OF INACTIVATING PYROGEN IN GLUCOSE INFUSION FLUID BY HEAT

对含５ ％ 或１０ ％ 葡萄糖注射液，先以１１５ ℃压力蒸汽加热处理４０ ｍｉｎ ，放置≥２４ ｈ ，再以１００ ℃加热处理４０ ｍｉｎ 。经检测，输液中热原被灭活，５ － 羟甲基糠醛量≤０ ．２４（ 吸光度值） ，符合我国《药典》规定（ ≤０ ．３２） 。

or10 % glucoseinfusion fluid wastreated by 115 ℃autoclaving for 40 min and then allowed to stand for ≥24 h ,followed by heating at 100 ℃for 40 min . Examination foundthatthe pyrogenintheinfusion fluid had beeninactivated andthe amountof5 - hydrox ymethylfurfural was ≤0 .24 (value of optic absorbance) which meets the value stipulated in pharmacopeia of PRC( ≤0 .32) .