1,3-二苯基-5-氯-吡唑-4-甲醛腙类化合物的合成

Synthesis of hydrazone derivatives of 1,3-diphenylpyrazole-4-formaldehyde

首先通过Vilismier反应得到的1,3-二苯基-5-氯-吡唑-4-甲醛与氨基硫脲反应制备了关键中间体1,3-二苯基-5-氯-吡唑-4-甲醛缩氨基硫脲。最后,经吡唑醛缩氨基硫脲中间体与7种不同的ω-溴代芳基乙酮反应合成了N-(1,3-二苯基-5-氯-吡唑-4-基)-N′-(芳基-噻唑-2-基)-甲醛腙类衍生物。利用元素分析、1HNMR、IR和MS谱确证了所得产物的结构。

1, 3-Diphenyl-5-chloro-pyrazole-4-thiosemicarbazone intermediate was 1,3-diphenyl-5-chloro-pyrazole-4-formaldehyde obtained via Vilsmeier-Hacck reaction of 1,3-diphenyl-5-choloro-pyrazol-4-formaldehyde with thiosemiearbazidea series of N-（1,3-diphenyl-5-chloro-pyrazole-4-yl）-N＇- （4-aryhhiazol-2-yl）-formaldehyde hydrazone derivatives were obtained via subsequent reaction with substituted ω-bromoacetophenone. Their structures were characterized by elemental analysis, IR, ^1 HNMR and MS spectra.