摘要
首先通过Vilismier反应得到的1,3-二苯基-5-氯-吡唑-4-甲醛与氨基硫脲反应制备了关键中间体1,3-二苯基-5-氯-吡唑-4-甲醛缩氨基硫脲。最后,经吡唑醛缩氨基硫脲中间体与7种不同的ω-溴代芳基乙酮反应合成了N-(1,3-二苯基-5-氯-吡唑-4-基)-N′-(芳基-噻唑-2-基)-甲醛腙类衍生物。利用元素分析、1HNMR、IR和MS谱确证了所得产物的结构。
1, 3-Diphenyl-5-chloro-pyrazole-4-thiosemicarbazone intermediate was 1,3-diphenyl-5-chloro-pyrazole-4-formaldehyde obtained via Vilsmeier-Hacck reaction of 1,3-diphenyl-5-choloro-pyrazol-4-formaldehyde with thiosemiearbazidea series of N-(1,3-diphenyl-5-chloro-pyrazole-4-yl)-N'- (4-aryhhiazol-2-yl)-formaldehyde hydrazone derivatives were obtained via subsequent reaction with substituted ω-bromoacetophenone. Their structures were characterized by elemental analysis, IR, ^1 HNMR and MS spectra.
出处
《化学试剂》
CAS
CSCD
北大核心
2011年第8期757-759,共3页
Chemical Reagents
基金
新疆维吾尔自治区自然科学基金资助项目(2009-211A02)
关键词
吡唑
噻唑
腙
合成
pyrazole
thiazole
hydrazone
synthesis