谷氨酸低分子量有机凝胶的药物控制释放行为

A L-glutamic acid based low molecular weight organogel as a vehicle for controlled drug release

低分子量的有机胶凝剂组装形成的有机凝胶可应用于药物缓释体系.本研究中,使用亲水的钙黄绿素和疏水的布洛芬为模型分子,研究其在谷氨酸衍生物有机凝胶体系中的缓释行为.研究表明,与药物分子与有机胶凝剂简单混合的体系相比,亲水或疏水的药物分子在有机凝胶体系中的释放速度显著减缓.SEM的研究发现药物粒子嵌入在有机凝胶的三维网络中,因此,有机凝胶的三维网络结构可认为是实现药物缓慢释放的基质,药物分子从网络中的释放受限导致了其从有机凝胶中的缓释行为.

Organogels formed by non-polymeric,low molecular weight organogelators have potentials to act as drug sustained release devices.Using hydrophilic calcein and lipophilic ibuprofen as model drugs,we studied the in vitro release behavior of the drugs loading into the glutamic acid based organogels.The in vitro release of drugs from the organogels is apparently slower than simple mixing.The SEM studies suggest that the drug particles are embedded into the networks formed by the self-assembled gelator fibers.Therefore,the networks of the organogels can be regarded as a matrix for the drugs release.The hindrance in diffusion of the drugs through the networks is proposed to be the mechanism of the drug sustained release in organogels.