摘要
沃尼妙林是新一代截短侧耳素(pleuromutilin)类抗生素。试验以丙烯酸树脂水分散体为肠溶包衣材料,单因素与正交试验筛选处方及工艺条件,用流化床包衣技术及挤出-滚圆法制备10%盐酸沃尼妙林肠溶微丸。研制的肠溶微丸外观、含量和释放度在加速试验条件下均保持稳定;以75~150 g/t饲料混饲给药,10%盐酸沃尼妙林肠溶微丸对猪痢疾有良好治疗效果,明显优于痢菌净。研究表明,盐酸沃尼妙林肠溶微丸质量符合药学要求,具有良好的体外肠靶向性,可用于猪肠道疾病的防制。
Valnemulin hydrochloride enteric pellets were developed by extrusion-spheronization and coated by fluid-bed with acrylic acid resin aqueous dispersion.The formulation and technology of valnemulin hydrochloride enteric pellets were selected by single-factor and orthogonal test.Its pharmacodynamics studies were also researched in this paper.The results showed that the coated pellets had smooth roundness,good reproductivity of inter-batch and good enteric-release property in vitro.In summary,the new productration possessed good vitro gut targeting by the optimal formulation and technology,and can be used clinically to prevent and treat swine dysentery.
出处
《中国兽医杂志》
CAS
北大核心
2011年第7期70-73,共4页
Chinese Journal of Veterinary Medicine
基金
国家自然科学基金资助项目(30771628)
关键词
盐酸沃尼妙林
肠溶微丸
挤出-滚圆法
药效学
valnemulin hydrochloride
enteric pellets
extrusion-spheronization
pharmacodynamic