儿童过敏性紫癜肾脏损害危险因素Logistic回归分析

Logistic regression analysis of the risk factors for kidney damage in children with Henoch-Schonlein purpura

目的:分析过敏性紫癜(HSP)患儿肾脏损害的相关危险因素。方法:对2008年8月至2010年8月住院确诊为HSP207例患儿的临床资料进行回顾性分析。结果:单因素分析年龄、临床类型、M、B、SD、PLT、PDW、CER、PTA、PTR、INR、APTT-R、AG、TP、ALB、GGT、LDH、TG、CHOL、CREA、IgG差异有统计学意义(P<0.05),年龄、皮疹反复、消化道症状、ALB、LDH在肾脏损害易感因素Logistic回归分析中有统计学意义(P=0.002、P=0.008、P=0.007、P=0.005、P=0.04)。结论:年龄、皮疹反复、消化道症状、ALB、LDH是HSP肾脏损害的危险因素,对于有上述因素的HSP患儿更应加强观察。

Objective To investigate the risk factors for kidney damage in children with Henoch-Schonlein purpura （HSP）. Methods Clinical data of 204 children with HSP from August 2008 to August 2010 were retrospectively analyzed. Results Univariate analysis indicated that age, clinical types, M, B, SD, PLT, PDW, CER, PTA, PTR, INR, AVIT-R, AG, TP, ALB, GGT, LDH, TG, CHOL, CREA, and IgG were significantly positive （P 〈 0.05）. The stepwise logistic regression analysis showed that age, repeated shin rash, gastrointestinal symptoms, ALB, and LDH were the risk factors for kidney damage in children with HSP （P = 0.002, P = 0.008, P = 0.007, P = 0.005, P = 0.04）. Conclusion Age, repeated shin rash, gastrointestinal symptoms, ALB, and LDH were the risk factors for kidney damage in children with HSP, patients who had these factors would need reinforced observation.