结直肠癌血清Nup88、CEA、CA19-9的表达及其临床意义

Expressions and Clinical Significance of Serum Nup88,CEA and CA19-9 in Colorectal Cancer Patients

目的观察核孔蛋白88(Nup88)、癌胚抗原(CEA)及糖类抗原19-9(CA19-9)在结直肠(CRC)癌患者血清中的表达水平,探讨其临床意义。方法收集结直肠癌患者84例(CRC组)及正常对照组106例;采用化学发光法测定血清中CEA、CA19-9的表达,采用双抗体夹心ELISA法测定血清中Nup88蛋白的表达水平。结果 CRC组血清CEA及CA19-9蛋白的表达明显高于正常对照组(P<0.05);CRC组血清CEA及CA19-9的阳性率分别为46.43%和22.62%,明显高于对照组的5.66%和10.38%;且血清CEA的表达与CA19-9的表达呈显著正相关(r=0.459,P<0.01)。CRC组患者血清中Nup88的表达水平与CEA及CA19-9的表达无明显相关性(r分别为0.13,0.206,P>0.05)。结论结直肠癌患者血清Nup88、CEA及CA19-9的高表达对结直肠癌的临床诊断可能具有一定意义。

Objective To investigate expressions and clinical significance of serum Nup88,CEA and CA19-9 in colorectal cancer patients.Methods Expressions of CEA and CA19-9 were detected by chemoluminescence immunoassay in 84 colorectal cancer patients and 106 healthy persons.Expression of Nup88 was detected by ELISA.Results Expressions of Nup88,CEA,and CA19-9 in patients with colorectal cancer were significantly higher than those in normal controls.The positive rates of CEA and CA19-9 in colorectal cancer patients were 46.43% and 22.62% respectively,higher than those in normal controls.Moreover,expression of CEA in colorectal cancer was positively correlated with CA19-9（r =0.459,P 〈 0.01）.However,serum Nup88 level was not correlated with CEA（P =0.24）or CA19-9（P =0.06）.Conclusion Overexpression of serum Nup88,CEA and CA19-9 might be useful for the clinical diagnosis of colorectal cancer.