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MDM2启动子309位点多态性与胶质母细胞瘤易感性的关系 被引量：4

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摘要 目的探讨MDM2基因启动子309位点多态性与胶质母细胞瘤(GBM)易感性的关系。方法应用PCR-RFLP技术分析95例GBM患者和95例健康对照者的MDM2启动子SNP309的基因型。结果 MDM2SNP309G/G基因型与T/T或T携带者(TT和TG)相比,均能增加GBM的患病风险(P<0.05)。结论 MDM2启动子309位点多态性与GBM易感性相关,其中SNP309G等位基因能增加CBM的患病风险。
作者 杨军 刘运海
机构地区 常宁市人民医院 中南大学湘雅医院
出处 《山东医药》 CAS 北大核心 2011年第29期87-88,共2页 Shandong Medical Journal
关键词 胶质母细胞瘤 MDM2 单核苷酸 多态性 SNP309
分类号 R739.4 [医药卫生—肿瘤]
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参考文献7

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同被引文献49

  • 1万军庭,李宝重,陈照丽,赫捷.MDM2启动子309位点多态性与肺癌易感性关系的Meta分析[J].中华肿瘤防治杂志,2008,15(9):655-658. 被引量：1
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引证文献4

山东医药
2011年 第29期

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