通心络胶囊对颈动脉支架置入术后炎性因子及缺血性脑血管事件的影响

Effect of Tongxinluo capsules on inflammation factors after carotid artery stenting and ischemic cerebrovascular incident

目的探讨通心络胶囊对颈动脉支架置入术后炎性因子及缺血性脑血管事件的影响。方法将67例颈动脉支架置入术患者随机分为对照组(35例)、治疗组(32例),对照组给予常规治疗,治疗组在常规治疗基础上加服通心络胶囊。测定2组患者术后1 h、2周、1和6个月白细胞介素6(IL-6)、TNF-α及C反应蛋白(CRP)水平,同时随访缺血性脑血管事件的发生。结果与术前比较,治疗组患者术后1 h CRP、IL-6、TNFα水平明显升高,术后2周CRP、TNF-α水平明显升高;对照组患者术后1 h、2周CRP、IL-6、TNF-α水平升高,术后6个月CRP、TNF-α水平明显升高(P<0.05,P<0.01)。与对照组比较,治疗组患者术后2周CRP、IL-6、TNF-α水平明显降低,术后1个月IL-6水平明显降低,术后6个月TNF-α水平明显降低,差异有统计学意义(P<0.05,P<0.01)。结论通心络胶囊可减轻颈动脉支架置入术后的炎性反应,对预防缺血性脑血管事件的发生可能有一定作用。

Objective To explore the effect of Tongxinluo capsules on inflammation factors after carotid artery stenting（CAS） and ischemic cerebrovascular incident. Methods Sixty-seven pa tients with carotid artery stenting were divided into control group（35cases） and treatment group （32cases） randomly. The control group took routine treatment and the treatment group took Tongxinluo capsules on the basis of routine treatment. The levels of interleukin 6（IL-6）,TNF-α and C-reactive protein（CRP） in the two groups were measured and compared 1 hour,2 weeks, 1 month,6 months after CAS. Ischemic cerebrovascular incident was observed as follow-up survey. Results Compared with before CAS,the levels of CRP,IL-6 and TNF-α 1 hour after CAS,and the levels of CRP and TNF-α 2 weeks after CAS increased obviously in treatment group, with sta tistical difference （P 〈 0.05,P 〈 0.01）. In control group,the levels of CRP,IL-6 and TNF-α 1 hour and 2 weeks after CAS and the levels of CRP and TNF-α 6 months after CAS increased obviously, with statistical difference （P 〈 0.05, P 〈 0.01）. Compared with control group, the levels of CRP,IL-6 and TNF-α 2 weeks after CAS,the level of IL-6 1 month after CAS and the level of TNF-α 6 months after CAS dropped obviously in treatment group,and there was statistical difference （P 〈 0.05,P 〈 0.01）. Conclusion Tongxinluo capsules can lighten inflammatory reaction after CAS and may have some help to prevent the occurrence of ischemic cerebrovascular incident.