葛根素对比维脑路通治疗椎-基底动脉供血不足的Meta分析

A Meta-analysis of Puerarin versus Venoruton for Vertebrobasilar Insufficiency

目的:评价葛根素制剂对比维脑路通制剂治疗椎-基底动脉供血不足(VBI)的疗效和安全性。方法:计算机检索Medline、EMbase、SCI、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP-维普)、中国生物医学文献数据库(CBM)、万方数据库,纳入葛根素对比维脑路通制剂治疗VBI的随机对照试验(RCT),对纳入研究进行质量评价,并对可合并结局指标进行Meta分析。结果:共纳入10个RCT,质量为C级。分析结果显示,两组总有效率、全血黏度、红细胞压积差异均有统计学意义:RR=[1.14,95%CI(1.09,1.20)]、MD=[0.97,95%CI(0.68,1.27)]、MD=[3.62,95%CI(1.08,6.16)]。结论:基于当前证据治疗VBI葛根素疗效优于维脑路通。

OBJECTIVE：To evaluate the effectiveness and safety of puerarin vs.venoruton for vertebrobasilar insufficiency（VBI）.METHODS：Medline,EMbase,SCI,CNKI,VIP,CBM and Wanfang database were searched,randomized controlled trials（RCT） of puerarin vs.venoruton for VBI were included,quality evaluation and meta-analysis were carried out.RESULTS：10 RCTs were gathered,graded C,Meta-analysis indicated the differences of total effective rate,blood viscosity and packed cell volume were significant：RR=[1.14,95%CI（1.09,1.20）],MD=[0.97,95%CI（0.68,1.27）],MD=[3.62,95%CI（1.08,6.16）].CONCLUSION：Based on current evidence,puerarin is better than venoruton in the treatment of VBI.