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抗抑郁药疗效的药物基因组学研究进展 被引量：3

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摘要 本文就与抗抑郁药疗效相关基因多态性的研究现状和进展作一综述。
作者 汤义平
机构地区 浙江省台州市第二医院
出处 《国际精神病学杂志》 2011年第3期179-181,141,共3页 Journal Of International Psychiatry
关键词 抗抑郁药 抑郁症 药物基因学 基因多态性 治疗
分类号 R749.053 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献7

  • 1Trivedi MH, Rush A J, Wisniewski SR, et al. Evaluation of outcomes with citalopram for depression using measurementbased care in STAR * D: implications for clinical practice. Am J Psychiatry, 2006 ; 163 ( 1 ) : 28 - 40.
  • 2Ito K, Weigl KE, Deeley RG, et al. residues in the NH2 - terminal region resistance protein, MRP1 ( ABCC1 ): expression, membrane localization, and Mutation ofproline of the muhidrug efects on protein transport function.BBA. 2003;1615(2) : 103 -114.
  • 3Uhr M, Tontsch A, Namendorf C, et al. Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008 ; 57 (2) : 203 - 209.
  • 4Dong C, Wong ML, Licinio J. Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2 : association with major depression and antidepressant response in Mexican - Americans. Mol Psychiatry, 2009;14(12) : 1105 - 1118.
  • 5Lee SH, Lee MS, Lee JH, et al. MRP1 polymorphisms associated with citalopram response in patients with major depression. J Clin Psychopharmacol, 2010 ; 30 ( 2 ) : 116 - 125.
  • 6Uher R, Perroud N, Ng MY, et al. Genome -wide pharmacogenetics of antidepressant response in the GENDEP project. Am J Psychiatry, 2010;167(5) : 555 -564.
  • 7Baune BT, Dannlowski U, Domschke K, et al. The interleukin 1 beta (ILIB) gene is associated with failure to achieve remission and impaired emotion processing in major depression. Biol Psychiatry, 2010 ;67 (6) : 543 - 549.

同被引文献30

  • 1Porcelli S,Drago A ,Fabbri C,et al. Phannacogenetics of anti?depressant response. Psychiatry Neurosci. 2011; 36 (2) : 87- 113.
  • 2Zackrisson AL, Lindblom B, Ahlner J. High frequency of oc?currence of CYP2D6 gene duplicationlmultiduplication indi?cating ultra rapid metabolism among suicide cases. Clin Phar?macol Ther. 2010;88:354-359.
  • 3Rudberg I,Mohebi B,Hermann M,et al. Impact of the ultrara- pid CYP2C 19 * 17 allele on serum concentration of escitalo?pram in psychiatric patients. Clin Pharmacol Ther. 2008; 83 : 322-327.
  • 4Uhr M, Tontsch A, Namendorf C, et al. Polymorphisms in the drug transporter gene ABCBl predict antidepressant treatment response in depression. Neuron. 2008; 57 ( 2) :203-209.
  • 5O'Brien FE, Clarke G, Fitzgerald P, et al. Inhibition of P - gly?coprotein Enhances Transport of the Antidepressant Imipra?mine across the Blood-Brain Barrier: Microdialysis Studies in the Conscious Freely Moving Rat. Br J Pharmacol. 2012,on?line.
  • 6Lin KM, Chiu YF, Tsai U, et al. ABCBI gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment. Pharmacogenet Genomics. 2011;21(4) :163-170.
  • 7Perroud N , Bondolfi G, Uher R,et al. Clinical and genetic cor?relates of suicidal ideation during antidepressant treatment in a depressed outpatient sample. Pharmacogenomics. 20 II ; 12 (3) :365-377.
  • 8Menu P, Gressier F, Verstuyft C, et al. Antidepressants and ABCB I gene C3435T functional polymorphism: a naturalistic study. Neuropsychobiology, 2010 ; 62 ( 3) : 193- 197.
  • 9Takashi F , Miho 0, Hiroaki H, et al. Association between the functional polymorphism ( C3435T) of the gene encodingP?glycoprotein ( ABCBl ) and major depressive disorder in the Japanese population. Journal of Psychiatric Research, 2012; 46: 555-559.
  • 10Uher R,Perroud N,Ng MY,et al. Genome-wide pharmaco?genetics of antidepressant response in the GENDEP project. Am J Psychiatry ,2010; 167 :555-564.

引证文献3

二级引证文献4

国际精神病学杂志
2011年 第3期

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