被动吸烟与宫颈癌关系的Meta分析

Meta-analysis of the relationship between passive smoking and cervical cancer

目的利于Meta分析的方法系统评价被动吸烟与宫颈癌的关系。方法检索2000～2009年Elsevier、中国期刊网、万方数据知识平台等已经发表的关于被动吸烟和宫颈癌关系研究的文献。纳入标准为涉及被动吸烟和宫颈癌关系的病例对照研究，各文献研究方法相似，有综合的统计指标。剔除不符合纳入标准，且重复研究报告及数据不完整的文献。利用Review Manager4．2软件进行统计分析。结果将14个研究结果加权合并，累计病例2612例，累计对照3050例，被动吸烟与宫颈癌有关联（Z=4．34，P〈O．0001），合并计算的OR=1．62，其95％a：1．30～2．01。结论被动吸烟是宫颈癌发生的一个危险因素。

Objective To systematically evaluate the relationship between passive smoking and cervical cancer （CC） by Meta-analysis. Methods Literatures which have been already published from 2000 to 2009 on the relationship between passive smoking and CC were searched through Elsevier, CNKI, ChinaInfo and so on. The inclusion criteria of literatures were case-control study associated with passive smoking and CC, studies with similar research methods and with a comprehensive statistical index. The literatures those didn＇ t accord with the standard, those repeated reports and those with incomplete data were excluded. Review Manager 4.2 software was applied to analyze data. Results After weightedly merged the results of 14 literatures, a total of 2 612 cases and 3 050 controls were collected. The association between passive smoking and CC was significant （ Z = 4.34, P 〈 0.0001 ）. The pools OR value was 1.62 and the 95 % CI of OR value was 1.30-2.01. Conclusion Passive smoking is a risk factor of cervical cancer.