高敏C反应蛋白血清BNP水平与心衰程度关系的研究

Study of association between high sensitivity C-reactive protein blood-serum BNP levels and congestive heart failure degree

目的观察心衰患者血清B型钠利尿肽(BNP)、高敏C反应蛋白(hsCRP)的水平变化,研究BNP、hsCRP与心功能状况之间的关系。方法本研究选择心力衰竭患者50例,正常对照45例,观察其BNP和hsCRP的变化。结果心衰患者的BNP和hsCRP较对照组明显升高,随着心功能状态的恶化,BNP和hsCRP逐渐升高,且心力衰竭越重,BNP和hsCRP水平越高,两组对比差异具有统计学意义(P<0.05,P<0.01)。结论血清BNP和hsCRP测定可以作为临床上判断心力衰竭程度的一个参考指标,对评估心衰患者的病情和临床疗效一定的价值。

Objective To observe the changes of blood - serum high sensitivity C - reactive protein, BNP level, and study the association between high sensitivity C - reactive protein, blood - serum BNP level and congestive heart failure patients. Methods The blood - serum BNP and high sensitivi- ty C -reactive protein concentration in 50 patients with congestive heart failure and 45 controls were determined and contrasted. Results The blood -serum BNP and high sensitivity C -reactive protein levels in congestive heart failure patients was significantly higher than that of the controls （P 〈 0.05, P 〈 0.01 ）. And with the increase of degree of congestive heart failure, the blood - serum BNP and high sensitivity C -reactive protein levels gradually increased. Conclusions The assay of the blood - serum BNP and high sensitivity C -reactive protein concentration is one reference index in judgement of the degree of congestive heart failure,and play an important role in the classification of cardiac function and clinical curative effect.