肺恶性肿瘤患者下呼吸道感染的病原菌及耐药性分析

Analysis of drug resistance and pathogenic bacteria in lung cancer patients with lower respiratory tract infection

目的探讨肺恶性肿瘤患者呼吸道感染病原菌分布及抗菌素的耐药情况。方法回顾分析2006年5月至2009年5月286例住院肺恶性肿瘤患者下呼吸道感染的病原菌以及耐药性的检测结果。结果下呼吸道感染的病原菌主要为革兰阴性杆菌(50.70%),其中铜绿假单菌比重最高(18.18%),大肠埃希菌第二(13.64%),肺炎克雷伯菌第三(11.19%),革兰阳性(G+)球菌占20.28%,真菌高达29.02%。病原菌对常用抗菌药物有很高的耐药性,革兰阴性杆菌对亚安培南的敏感性最高,其次是头孢哌酮、环丙沙星、阿米卡星。革兰阳性球菌敏感性最高为万古霉素。结论肺恶性肿瘤患者合并下呼吸道感染要及时做病原菌及耐药性分析,合理应用抗生素,降低耐药菌对恶性肿瘤患者的危害。

Objective To investigate respiratory tract infection pathogens in patients with lung cancer and antibiotic resistance of the distribution. Methods Retrospective analysis of our hospital in May 2006 - May 2009 totally 286 cases of lung cancer patients hospitalized with lower respiratory tract infection pathogens and drug resistance testing, the results were analyzed. Results Lower respiratory tract infection pathogens mainly Gram - negative bacilli （50. 70% ）, of which the highest proportion of Pseudomonas aeruginosa bacteria （ 18.18% ）, Escherichia coli II （ 13.64% ）, Klebsiella pnemnoniae third （ 11.19 % ）, Gram - positive （ G ＋ ） cocci accounted for 20.28%, fungi up to 29.02%. Patho- gens to commonly used antibiotics has a high resistance of Gram - negative bacilli sensitive to Imipen- em, followed by cefoperazone, ciprofloxacin, amikacin. Gram- positive cocci highest susceptibility to vancomycin. Conclusions Lung cancer patients with lower respiratory tract infection pathogens and drug resistance in time to do analysis, rational use of antibiotics to reduce the harm resistant to the cancer patients.