新生儿高胆红素血症90例临床分析

Neonatal hyperbilirubinemia of 90 Cases

目的探讨新生儿高胆红素血症的病因及相关因素,为临床提供早诊断早治疗的依据。方法采取回顾性调查方法对90例新生儿高胆红素血症病因进行综合分析。结果新生儿高胆红素血症的病因以围产因素为主,占43.3%,葡萄糖-6磷酸脱氢酶(G-6PD)缺乏占18.0%,ABO溶血病占15.3%,感染占14.0%,原因不明占9.4%。其中发病日龄在生后7d内占84.7%。围产期因素所致新生儿高胆红素血症的发病率高于其他致病因素,差异有统计学意义(P<0.05)。治愈75例(83.3%),好转11例(12.2%),自动出院4例(4.4%)。结论对于新生儿高胆红素血症应早期诊断,寻找病因,以光疗为主的综合治疗预后良好。

Objective To investigate the causes of neonatal hyperhilirubinemia and related factors to improve neonatal hyperbilirubinemia on the understanding of risk factors for clinical provide the basis for early diagnosis and early treatment. Methods A retrospective investigation of 90 cases of neonatal hyperbilirubinemia in a comprehensive analysis of the cause. Results The etiology of neonatal hyper- bilirubinemia to perinatal factors, accounting for 43.3 % , a glucose 6 phosphate dehydrogenase （ G - 6PD） lack accounting for 18.0%, ABO hemolytic disease 15.3%, infection 14. 0% ,9. 4% for un- known reasons. The incidence within 7 d after birth, accounting for 84. 7 %. Perinatal factors in neonatal hyperbilirubinemia due to high incidence of other risk factors, the difference was statistically significant （P 〈0. 05）. Cured 75 cases （83.3%）, improved in 11 cases （ 12.2% ）, discharged 4 cases （4. 4% ）. Conclusions The neonatal hyperbilirubinemia should be early diagnosis, search for a cause to light therapy combined therapy, the prognosis is good.