苯巴比妥佐治婴儿肝炎综合征的疗效分析

A study of therapeutic effect of phenobarbital on infantile hepatitis syndrome

目的探讨苯巴比妥佐治新生儿肝炎综合征的疗效。方法选取渭南市第一医院儿科就诊的婴儿肝炎综合征90例，随机分为对照组和治疗组，对照组采用一般药物治疗，治疗组在对照组的基础上加用苯巴比要治疗，每次5mg／kg，每日3次口服，并测定血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、γ-谷氨酰转肽酶（GGT）、碱性磷酸酶（ALP）、总胆红素（TBIL）、直接胆红素（DBIL）和间接胆红素（ram）含量。结果治疗组总有效率显著高于对照组（X^2=5．075，P〈0．05）；治疗组平均治疗天数显著短于对照组。对照组ALT、AST、TBIL、DBIL和m也治疗后与治疗前相比具有显著性差异（t值分别为20．85、25．13、25．11、27．86和23．17，均P〈0．05）；治疗组AIJ、AST、TBIL、DB几和m几治疗后与治疗前相比具有显著性差异（t值分别为23．23、25．49、27．22、33。07和27．72，均P〈0．05）；治疗组治疗后与对照组治疗后血清TBIL、DBIL和m几相比具有显著性差异（t值分别为7．81、6．71和5．35，均P〈0．05）；而对照组、治疗组治疗前后GGT、ALP未见统计学差异（均P〉0．05）。结论苯巴比妥佐治婴儿肝炎综合征近期疗效显著，值得推广。

Objective To study the therapeutic effect of phenobarbital on infantile hepatitis syndrome （IHS）. Methods Ninety infants with IHS were randomly divided into control group and treatment group. Infants in control group were treated with general drugs, while phenobarbital （5mg/kg, po rid） was supplemented to infants in treatment group based on general drugs. The contents of serum alanine aminotransferase （ ALT）, aspartate aminotransferase （AST）, gamma glutamyl transpeptidase （GGT）, alkaline phosphatase （ ALP）, total bilirubin （TBIL）, direct bilirubin （DBIL） and indirect bilirubin （IBIL） were determined for all infants. Results Total effective rate of treatment group was signifleantly higher than that of control group 0（2 = 5. 075, P 〈0.05 ）, and the average treatment duration of treatment group was significantly shorter than that of control group. There were significant differences in the contents of ALT, AST, TBIL, DBIL and IBIL before and after treatment in eantrol group （t was 20.85, 25.13, 25.11, 27.86 and 23. 17 respectively, P 〈0.05）. And in treatment group the contents of ALl＇, AST, TBIL, DBIL and IBIL before treatment were significantly different from those after treatment （t was 23.23, 25.49, 27.22, 33.07 and 27.72 respectively, P 〈 O. 05）. After treatment there were significant differences in the contents of serum TBIL, DBIL and IBIL between treatment group and control group （t was 7.81,6.71 and 5.35 respectively, P 〈0.05）, but there was not any statistical difference in GGT and ALP between two groups before and after treatment （ P 〉 O. 05 ）. Conclusion Phenobarbital is very effective in supplementary treatment of IHS and is worth popularizing.