胎膜早破孕妇血清白细胞介素18浓度的变化

Change of maternal serum interleukin-18 concentration in oremature runture of membranes

目的研究胎膜早破患者血清白细胞介素18浓度的变化。方法选择在苏州市立医院产科住院足月分娩的单胎初产妇共60例，其中正常孕妇30例（对照组），胎膜旱破患者30例（胎膜早破组），所有患者均在无宫缩时行剖宫产。所有入选的孕妇入院后行剖宫产前即抽取肘静脉血4mL，测定血清白细胞介素18的浓度。结果胎膜早破组血清白细胞介素18浓度为31．44±4．8pg／mL，对照组血清白细胞介素18浓度为7．7±4．1pg／mL。组间比较胎膜早破组血清白细胞介素18浓度显著高于对照组（t=20．5634，P〈0．05）。结论母血中白细胞介素18含量的变化提高了胎膜早破诊断的敏感性，并且有可能成为检测羊膜腔感染的指标。

Objective To observe the change of maternal serum interleukin-18 （IL-18） concentration in premature rupture of merabranes （PRM）. Methods Sixty primiparas with full-term single birth in maternity department of Suzhou Municipal Hospital were divided into control group （ normal pregnant women） and PRM group （women with PRM）, 30 patients in each group. All patients underwent cesarean section in the absence of contraction. 4ml elbow vein blood was drawn from each selected pregnant women before cesarean section and determined the concentration of maternal serum IL-18. Results The serum IL-18 concentration in PRM group （31.4 ＋ 4.8pg/mL） was significantly higher than that （7.7 ＋ 4. lpg/mL） in control group （t = 20. 5634, P 〈 0. 05）. Conclusion The change of IL-18 concentration in maternal serum increases the sensitivity of the diagnosisof PRM, and may be an indicator to detect intra-amniotic infection.