活动精子总数、精子形态与宫腔内人工授精妊娠率的关系

Effect of sperm normal morphology rate and total motile sperm number on intrauterine insemination pregnancy rate

目的探讨在宫腔内人工授精(IUI)过程中,处理后A、B级精子总数、精子正常形态率与IUI临床妊娠率的关系。方法回顾该院2009年1月1日～8月31日330周期IUI的资料,比较了处理后A、B级精子总数、精子正常形态率对IUI临床妊娠率的影响。结果①治疗周期中排卵前后两次授精A、B级精子总数均≥(10×106)和均<(10×106)相比,其临床妊娠率分别为21.6%和9.0%,差异有显著性(P<0.05);若排卵前授精≥(10×106),排卵后<(10×106),其临床妊娠率为15.1%,与上述两组相比亦差异有显著性(P<0.05);②精子正常形态率<6%与精子正常形态率6%～10%、≥10%相比,其临床妊娠率差异有显著性(P<0.05)。结论①用于宫腔内人工授精的精液需要有10×106以上的A、B级精子总数,且排卵前授精和排卵后授精有相似的重要性;②用于宫腔内人工授精的精液精子正常形态率≥6%可获得较高的临床妊娠率。

【Objective】 To study the relationship between total motile sperm number、sperm morphology and pregnancy rate in intrauterine insemination（IUI）.【Method】 By a retrospective survey on data of 330 cycles from January 2009 to August 2009 in our hospital,we studied influences of total motile sperm number（A,B grade）,sperm normal morphology rate on IUI pregnancy rate.【Result】 ① We compared the two groups of total motile sperm number ≥10×106 and 10×106 in two insemination cycles before and after ovulation,and found there was statistical difference between their pregnancy rates（21.6% vs 9.0%,P 0.05）;The group with total motile sperm number before ovulation ≥（10×106） and after ovulation （10×106） had a pregnancy rate of 15.1%,and there was also statistical difference from the other two groups（P 0.05）;②There was statistical difference between sperm normal morphology rate 6% and sperm normal morphology rate 6%～10%、≥10%（P 0.05）.【Conclusion】 ① Above（10×106） total motile sperms（A,B grade） are required for IUI;The importance of definite total motile sperm number is similar both in insemination before and after ovulation;② The semen of sperm normal morphology rate ≥6% for intrauterine insemination can get a higher pregnancy rate than sperm normal morphology rate 6%.