卡贝缩宫素防治妊娠合并子宫肌瘤剖宫产术后出血的疗效观察

Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section of pregnant women with uterine hysteromyoma

目的探讨卡贝缩宫素对于减少妊娠合并子宫肌瘤孕妇剖宫产术后出血的临床效果。方法55例妊娠合并子宫肌瘤的孕妇（子宫肌瘤直径≥2cm）随机分成2组，卡贝缩宫素组（28例）在术中单次静脉注射卡贝缩宫素100腭（1ml），两组术中宫体注射催产素20u，对照组（27例）产后继续静脉滴注催产素20u维持6h。观察两组术中和产后2h、6h、24h的出血量，手术前后血红蛋白值的变化。结果卡贝组有效促进子宫收缩并减少出血量26例，无效2例；对照组有效促进子宫收缩并减少出血量15例，无效12例。卡贝组术中及产后2h、6h、24h出血量均明显低于对照组（P〈0．05）。两组手术前后血红蛋白差值差异无统计学意义（P〉0．05）。结论卡贝缩宫素可有效促进子宫收缩且减少妊娠合并子宫肌瘤孕妇剖宫产术中术后出血量。

Objective To study the clinical effects of earbetocin to reduce maternal hemorrhage after cesarean section of pregnant women with hysteromyoma.Methods 55 pregnant women with hystemmyoma（ diameter of hystemmyma ≥ 2 cm）were randomly divided into two greups：carbetocin group（28 women）received carbetocin 100 μg（1 ml）intravenously after the delivery of the baby,and control group（27 women）received oxytocin 20U intravenously after the delivery of the baby and 20 U by ivgtt for 6h postpartum. The amount of bleeding during operation and 2, 6 and 24h postpartum were observed.The perioperative haemoglobin values were observed. Results The amount of bleeding in earbetcoin group were less than that of control group during operation and 2,6 and 24 h postpartum.There were no significant differences in the periopemtive haemoglobin values between the two groups. Corlelusion Carbetecin can promote uterine contraction effectively and reduce the amount of bleeding.