蒿甲醚缓释片体外释放研究

Release in vitro of Delayed released Artemether Tablet

目的:建立蒿甲醚缓释片体外释放的含量测定方法,并对其进行体外释放考察。方法:以释放介质作为酸消解溶剂,用酸消解间接紫外分光光度法测定片剂在释放过程中的累计百分释放度;浆法考察片剂的体外释放。结果:优选了最佳酸消解条件,并确定了片剂体外释放含量测定方法:蒿甲醚缓释片2h,5h,10h的体外累计百分释放度分别为25%,60%,85%;在诸多因素中离子强度是影响缓释片释放较灵敏的因素。结论:方法准确、快速、可行,适于体外释放实验样品量大的要求;体外实验表明蒿甲醚缓释片具有比普通片明显的缓释效果。

OBJECTIVE: To establish determination method of Artemether during release in vitro of delayed released Artemether tablet and to investigate its behavior in vitro. METHODS: Release medium was used as an acidic hydrolytic solvent and acid hydrolytic indirect UV spectrophotometer was used for determination of accumulate percent release rate in vitro and paddle method for release study in vitro. RESULTS: The best condition of acidic hydrolytic was selected and the determination method in vitro release was defined; the accumulative released percentage from delayed release Artemether tablet was 25%, 60%, 85% respectively in 2 nd ,5 th ,10 th hour; ionic strengths greatly affected the release from delayed release Artemether tablet in investigated factors. CONCLUSION: The method was accurate, fast and applicable for release study in vitro with of many samples and jobs.$$$$