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溴隐亭治疗泌乳素大腺瘤的临床观察 被引量:1

Efficacy and safety of bromocriptine as first line treatment for macroprolactinoma
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摘要 目的:探讨溴隐亭治疗泌乳素大腺瘤的方法、效果及不良反应。方法:回顾性分析单纯溴隐亭治疗9例泌乳素大腺瘤的长期随访结果。结果:溴隐亭的开始剂量为1.25~2.5 mg.d-1、分2~3次口服,在6个月内缓慢增至5~15 mg.d-1。平均随访58.3个月,最后随访时血泌乳素(prolactine,PRL)恢复正常8例(88.89%)、肿瘤体积平均缩小(81.3±23.9)%。治疗期间大部分原发症状好转,出现头晕2例、脑脊液漏1例。结论:溴隐亭单药治疗泌乳素大腺瘤能明显降低血PRL、缩小肿瘤体积及改善临床症状,且不良反应少。 OBJECTIVE To investigate the methods, efficacy and safety of bromocriptine as first line treatment for macrop rolactinoma. METHODS Retrospectivly analyse the long-term follow-up datas of 9 cases of macroprolactinoma treated with bromocriptine. RESULTS Bromocriptine was initiated with a dose of 0. 625- 1.25 mg daily given in twice or thrice, and a dose generally of 5-15 mg daily was gradually reached in 6 months. In the mean follow-up period of 58. 3 months, 8 patients have normalized their prolactin levels, the mean reduction in tumor volume was (81.3 ± 23.9)%0. Most of the symptoms caused by tumor or hyperprolactinemia were improved, and 2 cases of dizziness and 1 case of cerehrospinal fluid leakage happened during the therapy. CONCLUSION Bromocriptine monotherapy is effective and well tolerated for macroprolactinoma.
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2011年第15期1271-1274,共4页 Chinese Journal of Hospital Pharmacy
关键词 溴隐亭 泌乳素大腺瘤 bromocriptine macroplactinoma
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  • 1龙入虹,韦秀英.泌乳素腺瘤临床特点和生物学行为的性别差异[J].海南医学,2006,17(4):131-133. 被引量:1
  • 2Leong KS, Foy PM, Swift AC, et al. CSF rhinorrhoea following treatment with dopamine agonists for massive invasive prolactinomas[J]. Clin Endocrino (Oxf), 2000, 52( 1): 43-49.
  • 3Pascal-Viqneron V, Weryha G, Braun M, et al. Rhinorrhea and otorrhea: rare complications of the medical treatment in invasive prolactionmas[J]. Ann Endocrinol (Pads), 1994, 54(5): 347-351.
  • 4Bronstein MD, Musolino NR, Benabou S, et al. Cerebrospinal fluid rhinorrhea occurring in long-term bromocriptine treatment for macroplactinomas[J]. Surg Neurol, 1989, 32(5): 346-349.
  • 5Barlas O, Bavindir C, Hepgil K, et al. Bromocriptine-induced cerebrospinal fluid fistula in patients with macroprolactinomas: report of three cases and a review of the literature[J]. Surg Neurol, 1994, 41(6): 486-489.
  • 6Nomikos P, Buchfelder M, Fahlbusch R. Current management of prolactinomas[ J]. J Neuroonco1,2001,54(2) :139 - 150.
  • 7Wang RZ,Ren ZY,Su CB, et al. Prolactinoma in male[J]. Chin J Neurosurg, 2000,16( 1 ) :139 - 142.
  • 8AsanoS,UekiIK,KirinoT.Clinicalfeaturesandmedicaltreatmentofmaleprolactinomas[].ActaNeurochirWien.2001
  • 9LohKC,ShlossbergAH.Largemacroprolactinomatreatedwithbromocriptinealone[].AnnAcadMedSingapore.1996
  • 10MinnitiG,Jaffrain-ReaML,SantoroAetal.Giantprolactinomaspresentingasskullbasetumors[].Surgical Neurology.2002

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