他汀类药物降低血液透析患者微炎症及尿酸水平临床观察

Effects of statins on microinflammatory and peruricemia process in Hemodialysis patients

目的分析及观察他汀类药(氟伐他汀)对尿毒症血液透析患者微炎症状态及血尿酸水平的临床疗效。方法选择襄樊市第一人民医院透析中心49例行透析3年以上的患者为观察对象,分别对照治疗前及氟伐他汀治疗24周后血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高敏C反应蛋白(hs-CRP)、白介素6(IL-6)和血尿酸。结果血液透析患者存在高炎症状态,经过氟伐他汀治疗24周后,血液透析患者的血LDL-C、hs-CRPI、L-6和尿酸水平均有显著降低,与治疗前比较,有显著性差异(P<0.05)。结论他汀类药能明显改善血液透析患者的微炎症状态及血尿酸水平。

Objective To investigate effects of fluvastatin on microinflammatory and peruricemia process in hemodialysis patients.Methods Forty-nine cases of more then three-years dialysis patients of the first people＇s Hospital of Xiangfan were all treated with fluvastatin,before and 24 weeks after the treatment of fluvastatin,fasting total serum cholesterol,Low-density lipoprotein（LDL）、triglycerides and serum high-sensitivity C-reactive protein（hs-CRP）、interleukin-6（IL-6） and peruricemia were all measured.Results Dialysis patients were all in high inflammation state.After 24 weeks treatment of fluvastatin,patients＇ low-density lipoprotein and hs-CRP,IL-6 and peruricemia levels were significantly lower,compared with the pre-treatment,the difference was significant（P〈0.05）.Conclusions Statins can significantly improve the micro-inflammatory state and peruricemia levels of dialysis patients.