环磷酰胺两种给药方案治疗小儿难治性肾病综合征的对比观察

Comparative Observation of Two Dosing Regimens of Cyclophosphamide Treatment of Pediatric Nephrotic Syndrome

目的探讨静滴环磷酰胺间断冲击与连续冲击两种给药方式治疗小儿难治性肾病的临床疗效。方法对2001年1月-2008年1月15例难治性肾病患儿应用环磷酰胺两种给药方式，观察药效学。结果在间断静脉冲击组8例中，治疗显效6例，有效1例，无效1例（占12．5%），总有效率（占87．5%），副作用，除1例恶心呕吐外，未发现其它副作用均能完成疗程。连续冲击组显效4例，有效2例，无效1例（占14．29呦，总有效率（占85．71%），副作用有恶心呕吐4例。感染严重脱发和白细胞减少各3例。结论对于小儿难治性肾病选用免疫抑制剂CTX时，采用静脉间断冲击治疗方法效果好，副作用少，可作为首选方案。

Objective To investigate the impact of intermittent and continuous intravenous cyclophosphamide pulse therapy in children with refractory nephropathy. Methods from January 2001 to January 2008 15 cases of children with primary nephrotic application cyclophosphamide amide two delivery methods, pharmacodynamics observed. Results In 8 cases the impact of intermittent intravenous in the treatment of 6 cases markedly effective in 1 case, 1 patient （12.5%）, the total effective rate （87.5%） side effects of nausea and vomiting in 1 patient, but did not find the other side can complete the therapy. Continuous shock group, excellence in 4 cases, 2 cases, 1 patient （14.29%）, total effective rate （85.71%）. Side effects are nausea and vomiting in 4 cases, severe infection of the hair loss and leukopenia in 3 patients. Conclusion For children with nephrotic CTX immunosuppression used, the impact of treatment with intravenous intermittent effect, less side effects, can be used as the preferred program.