清肝益气降压方配伍针刺对高血压大鼠血清一氧化氮、血浆内皮素的影响

Effects on Hypertension Model Rats Through Compatibility of Chinese Medicine and Acupuncture

目的:观察清肝益气降压方配伍针刺太冲、太溪、足三里对高血压大鼠血压、血浆内皮素、血清一氧化氮的影响,探讨方药和针刺不同穴位的交互作用及其内在的机理。方法:采用正交设计安排实验,将造模成功大鼠分别给予清肝益气降压方和针刺,连续治疗2周后,测定大鼠血压、血浆内皮素、血清一氧化氮。结果:清肝益气降压方配伍针刺能使ET含量降低,NO含量升高,使血压降低,优于单纯针刺和方药组(P<0.05)。结论:针刺和药物间产生协同作用,可以按照中医辨证施治原则配伍使用。针刺和方药对各项指标的影响程度不一,可能这种多靶点、多途径、多层次的作用方式,是针药产生协同作用的基本原因。

Objective ： By observing the effects on hypertension model rats with the formula （ named removing heat from the liver and enriching Qi, hereafter the formula ） and acupuncturing Zusanli （ ST36 ）, Taichong （ LR3 ） and Taixi （ KI3 ）, the dissertation aims to discuss the interactive mechanism of prescription medicine and acupuncture. Method：The project applies the orthogonal design to arrange experiment, respectively gave the formula and acupuncturing to the successfully made model rats for two weeks continuously, then determining their blood pressure, ET, NO. Results：The experimental results indicate that the formula and acupuncture has apparent effect of lowering the blood pressure. The best treatment project on the basis of blood pressure change is the formula matching with acupuncturing Taichong （ LR3 ） and Taixi （ KI3 ）. Conclusion ： The acupuncture and Chinese medicine can be matched under the TCM syndrome differentiation treats principles.