摘要
目的:探讨平喘宁治疗哮喘的作用机制。方法:用放射性免疫法(RIA)测定豚鼠支气管肺泡灌洗液(BALF)中IL-4、血浆中TXB2、6-Keto-PGF1α在平喘宁治疗哮喘前后的变化。结果:平喘宁能显著降低豚鼠BALF中IL-4、血浆TXB2水平,提高血浆6-Keto-PGF1α的水平。结论:平喘宁通过降低豚鼠BALF中IL-4、血浆中TXB2水平,提高血浆6-Keto-PGF1α的水平,从而减轻气道炎症反应,缓解气道平滑肌痉挛而发挥治疗哮喘的作用。
Objective:The article was to investigate the role mechanism of treating asthma by Pingchuanning.Methods:The change of IL-4 in bronchoalveolar lavage fluid(BALF) and TXB2,6-Keto-PGF1α in plasma of guinea pigs were Observed by radioactive immunoassay(RIA) with treatment of Pingchuanning.Results:Pingchuanning could significantly reduce the content of IL-4 in BALF and TXB2 in plasma,increase the content of 6-Keto-PGF1α in plasma in guinea pigs with asthma.Conclusion:Pingchuanning can reduce airway inflammation,relieve airway smooth muscle spasm by decreasing IL-4 in BALF and TXB2 in plasma,improving 6-Keto-PGF1α in plasma,thereby play a role in the treatment of asthma.
出处
《辽宁中医药大学学报》
CAS
2011年第8期29-31,共3页
Journal of Liaoning University of Traditional Chinese Medicine
基金
安徽省教育厅自然科学重点研究项目(KJ2009A042Z)
安徽省自然科学基金项目(03043004)