无创正压通气治疗急性肺损伤

Effect of noninvasive positive pressure ventilation in the treatment of the patients with acute lung injury

目的:评价无创正压通气(NPPV)治疗急性肺损伤(ALI)临床治疗效果。方法:回顾性分析我院重症监护病房(ICU)2001年1月～2010年12月救治的124例ALI病例资料。以时间前(2001年1月～2005年12月)后(2006年1月～2010年12月)分为对照组和治疗组,2006年1月后收治患者(治疗组)采用了NPPV治疗。结果:治疗组NPPV治疗2、72 h后,与对照组同一时间段比较氧合指数明显增加(P<0.05),并保持较高水平,治疗组在患者滞留ICU时间、无创通气率及住院死亡率均明显降低(P<0.05)。结论:NPPV治疗明显降低了ALI患者有创通气率,减少了ICU滞留时间和住院死亡率。

Objective： To evaluate the clinical effect of noninvasive positive pressure ventilation （NPPV） in the treatment of the patients with acute lung injury （ALl）. Methods： The clinical data of 124 inpatients with acute lung injury in intensive care unit （ICU） of our hospital from January 2001 to December2010 were reviewed. The patients were divided into control group （January 2001 to December 2005） and treatment group （January 2006 to December 2010）. The treatment group （after January 2006） was treated with the NPPV. Results： In the treatment group, oxygenation index of NPPV 2 h, 72 h was significantly increased （P〈0.05） than that of the control group, and maintained a high level. Time of staying in ICU, non-invasive ventilation and hospital mortality rates were significantly lower compared with those of the control group （P〈 0.05）. Conclusion： NPPV treatment has a significantly lower rate of invasive ventilation in patients with ALI, can reduce the residence time of ICU and mortality rate.