摘要
目的：考察实验温度对盐酸氮芥含量测定结果的影响。方法：在5—30℃之间设置6个温度点，分别在各个温度点下测定消白酊及10％盐酸氮芥溶液中盐酸氮芥含量的变化趋势。含量测定方法参照《中国药典）2010年版二部“盐酸氦芥注射液的含量测定方法”制定。结果：随着实验温度的升高，盐酸氮芥的含量测定结果逐渐升高，25℃以后不再变化。结论：实验温度低会造成化学反应不完全，使含量测定结果偏低，故盐酸氮芥的含量测定应不低于25℃，与室温接近。
Objective： To research the influence of experimental temperature on determinating chlormethine hydrochloride. Methods： Xiaobai tincture and 10% chlormethine hydrochloride were determinated in 6 temperature points during 5℃ to 30℃, then observed the variation trend of the measured results. The determination method was drew up which took the method of determinating chlormethine hydrochloride injection on Ch.p 2010（2） as reference. Results： The measured results rised as the experimental temperature rising, and was stable at about 25℃. Conclusion： Low temperature can cause inadequate chemical reaction and also decrease the measured results, so the experimental temperature of determinating ehlormethine hydrochloride should be controlled at about 25℃ which is closed to room temperature.
出处
《中国医药导报》
CAS
2011年第23期61-62,共2页
China Medical Herald
关键词
盐酸氮芥
含量测定
实验温度
Chlormethine hydrochloride
Determination
Experimental temperature
