中医医院耐药葡萄球菌属检测分析

Detection of staphylococcus in hospital of traditional Chinese medicine

目的了解医院2008年10月-2010年4月门诊和住院患者耐药葡萄球菌属感染现状,为临床抗感染治疗提供依据。方法同步检测葡萄球菌属产β-内酰胺酶菌株、耐甲氧西林葡萄球菌菌株、红霉素诱导克林霉素耐药菌株等3种类型耐药菌的耐药表型。结果 141株葡萄球菌属中产β-内酰胺酶菌株阳性率95.7%;耐甲氧西林葡萄球菌(MRS)阳性率63.8%;红霉素诱导克林霉素耐药菌株阳性率(D试验阳性)39.0%;红霉素耐药率高达91.5%;克林霉素非诱导耐药率为41.1%,克林霉素总耐药率为80.0%;红霉素诱导克林霉素耐药菌株在MRS中为36.9%,甲氧西林敏感葡萄球菌(MSS)中为43.3%。结论注重葡萄球菌属多种耐药性检测,根据药敏结果合理应用抗菌药物。

OBJECTIVE To understand the infection condition and drug resistance superficies of Staphylococcus in our hospital from Oct 2008 to Apr 2010 and offer suggestions for treatment of clinical infection.METHODS K-B method was used for β-lactam enzyme,MRS and CM inductivity drug resistance（D test） synchronization test of Staphylococcus.RESULTS In 141 individual Staphylococcus,β-lactam enzyme（＋） was 95.7%;MRS was 63.8%;D test（＋） was 39.0%,E drug resistance was 91.5%;CM non-inductivity drug resistance was 41.1%;CM totally drug resistance was 80.0%;D test（＋） Staphylococcus in MRS was 36.9%,in MSS was 43.3%.CONCLUSION It should pay attention to the multiple drug resistance of Staphylococcus and rationally select antibiotics based on drug susceptibility.