2007-2009年肿瘤医院感染病原菌分布及其耐药性调查分析

Distribution of pathogenic bacteria causing clinical infection and investigation of drug resistance during 2007-2009

目的分析肿瘤患者医院感染的病原菌分布及耐药性,为临床合理用药和控制医院感染提供依据。方法对2007-2009年细菌室分离出的980株临床病原菌进行统计及耐药分析。结果病原菌以革兰阴性杆菌为主,占50.7%,真菌占34.3%,革兰阳性球菌占15.0%;3年中革兰阴性杆菌和真菌检出构成比例逐年上升,革兰阳性球菌检出比例呈逐年降低趋势,革兰阴性杆菌对氨苄西林、哌拉西林、庆大霉素和妥布霉素的3年平均耐药率>70.0%;革兰阳性球菌对青霉素和环丙沙星的3年平均耐药率>70.0%;真菌对两性霉素B和制霉菌素耐药率<6.0%。结论重视肿瘤患者病原菌医院感染的病原学检查和药敏监测,才能有效地控制病原菌医院感染。

OBJECTIVE To analyze the pathogens in tumor patients with nosocomial infection and their resistance.In order to provide evidence for the guidance of clinical rational administration and to decrease the nosocomial infection.METHODS A total of 980 strains of clinical pathogenic bacteria isolated by bacteriology laboratory and drug resistance from 2007 to 2009 were analyzed.RESULTS The main pathogenic bacteria were the Gram-negative bacilli（50.7%）.And the second pathogenic bacteria were the fungi（34.3%）.The Gram-positive cocci（15.0%） The constituent ratio of the detection in Gram-negative bacilli ncreased year by year in the last three years,while the detection in Gram-positive cocci decreased.The 3-year average rate of drug resistance of Gram-negative bacilli to ampicillin,piperacillin,gentamicin,tobramycin were over 70.0%,and the 3-year average rates of drug resistance of Gram-positive cocci to ampicillin and ciprofloxacin hydrochloride were also over 70.0%.The drug resistance rate to amphotericin B and nystatin were 6.0%.CONCLUSION We should think highly of etiological detection and monitoring of drug resistance in pathogen nosocomial infections in tumor patients in order to control the infections effectively.