脑脊液S-100b蛋白与IL-6检测在中枢神经系统感染患儿诊断中的价值研究

Value of detecting cerebrospinal fluid S-100b protein and IL-6 in diagnosis of central nervous system infections in pediatric patients

目的探讨脑脊液S-100b蛋白与IL-6水平在中枢神经系统感染患儿诊断中的临床价值。方法采用酶联免疫吸附试验(ELISA)检测31例化脓性脑膜炎和45例病毒性脑膜炎患儿急性期和恢复期脑脊液S-100b蛋白与IL-6水平,并与对照组进行比较分析。结果化脓性脑膜炎组脑脊液中S-100b蛋白与IL-6急性期检测水平分别为(512.7±153.6)ng/L和(318.4±72.5)ng/L;病毒性脑膜炎组脑脊液中S-100b蛋白与IL-6急性期检测水平分别为(396.0±108.9)ng/L和(126.5±37.3)ng/L;对照组脑脊液中两项检测水平分别为(131.3±9.5)ng/L和(49.8±8.2)ng/L;化脓性脑膜炎组和病毒性脑膜炎组脑脊液的急性期两项检测水平显著高于其恢复期和对照组水平,差异有统计学意义(P<0.01)。结论 S-100b蛋白与IL-6是评价中枢神经系统感染早期炎症损伤程度的重要指标。

OBJECTIVE To explore the clinical value of detecting cerebrospinal fluid S-100b protein and IL-6 in children with central nervous system infection.METHODS The levels of S-100b protein and IL-6 in CSF were detected by ELISA in 31 cases with purulent meningitis and 45 cases with viral encephalitis in acute phase and recovery phase,and the results were compared with control cases.RESULTS The levels of S-100b and IL-6 in CSF of purulent meningitis were（512.7±153.6）ng/L and（318.4±72.5）ng/L;Their concentration in viral meningitis were（396.0±108.9）ng/L and（126.5±37.3）ng/L;Their concentration in control group were（131.3±9.5）ng/L and（49.8±8.2）ng/L.The levels of S-100b and IL-6 in acute stage were significantly higher than those of the cases in convalescent stage and control group（P0.01）.CONCLUSION S-100b and IL-6 are the important indicators for the estimation of the severity of early inflammation injury in central nervous system infection.