中枢神经系统感染患儿脑脊液IL-6、β2-MG检测的临床意义

Clinical significance of determination of CSF IL-6 and β_2-MG for infection of central nervous system in paediatric patients

目的研究脑脊液中白细胞介素-6(IL-6)和β2微球蛋白(β2-MG)在中枢神经系统感染患儿发病机制中的作用及其临床意义。方法应用酶联免疫(ELISA)双抗体夹心法测定脑脊液IL-6水平,应用速率散射比浊法(LAT)检测β2-MG水平。结果化脓性脑膜炎组脑脊液中IL-6和β2-MG急性期检测指标分别为(278.5±63.7)ng/L和(9.4±2.6)mg/L;病毒性脑膜炎组脑脊液中IL-6和β2-MG急性期检测指标分别为(101.2±30.5)ng/L和(5.1±1.7)mg/L;对照组脑脊液中两项检测指标分别为(47.0±6.1)ng/L和(1.8±0.5)mg/L;化脓性脑膜炎组和病毒性脑膜炎组的急性期两项检测指标显著高于其恢复期和对照组水平,差异有统计学意义(P<0.01)。结论脑脊液IL-6和β2-MG水平的测定对中枢神经系统感染患儿的鉴别诊断有重要临床意义。

OBJECTIVE To study the function and Clinical significance of CSF IL-6 and β2-MG in infection of the central nervous system in pediartic patients.METHODS IL-6 was determined by ELISA,β2-MG was determined by LAT.RESULTS The contents of IL-6 and β2-MG in CSF of purulent meningitis were（278.5±63.7） ng/L and（9.4±2.6） mg/L;Their contents in viral meningitis were（101.2±30.5） ng/L and（5.1±1.7） mg/L;Their contents in control group were（47.0±6.1） ng/L and（1.8±0.5） mg/L.The levels of IL-6 and β2-MG in acute stage were significantly higher than those of the cases in convalescent stage and control group（P0.01）.CONCLUSION It has great clinical significance to detect the levels of IL-6 and β2-MG for the differentiating diagnosis of paediatric patients with the central nervous system infection.