2006-2009年住院患者医院感染病原菌的分布及耐药分析

Distribution of pathogenic bacteria causing hospital acquired infections and drug resistance from 2006 to 2009

目的探讨医院感染病原菌分布及耐药性,为预防和控制医院感染提供理论依据。方法对2006年1月-2009年12月住院患者发生医院感染的病原菌及耐药情况进行回顾性分析。结果 4年来共分离2462株病原菌,其中革兰阴性杆菌1596株,占64.83%;革兰阳性球菌540株,占21.93%;真菌326株,占13.24%;耐药率居首位的为铜绿假单胞菌,其次为大肠埃希菌,金黄色葡萄球菌对青霉素、红霉素耐药率最高。结论医院感染以革兰阴性杆菌为主,对常用抗菌药物耐药率较高,定期对细菌耐药性监测,为临床合理使用抗菌药物、控制医院感染具有重要意义。

OBJECTIVE To study the distribution of pathogenic bacteria of hospital acquired infections and the drug resistances and to provide valuable data for infection prevention and treatment.METHODS A retrospective investigation analysis was made for all the isolated pathogenic bacteria and its drug resistance of inpatients from Jan 2006 to Dec 2009.RESULTS Totally 2462 bacterial strains were isolated including 1596 strains of Gram-negative bacteria（64.82%）,540 strains of Gram-positive bacteria（21.93%） and 326 strains of fungi（13.24%）.The resistant rate of Pseudomonas aeruginosa ranked the first,the second was Escherichia coli.The resistant rate of Staphylococcus aureus against penicillin or erythromycin was highest.CONCLUSION The majority of pathogens of hospital acquired infections are Gram-negative bacteria,and the resistant rate against routine antimicrobial agents is high.It is useful to detect bacterial drug-resistances for antibiotics used rationally and control hospital intersect infection.